An Epstein-Barr virus immediate-early gene product trans-activates gene expression from the human immunodeficiency virus long terminal repeat.
An Epstein-Barr virus immediate-early gene product trans-activates gene expression from the human immunodeficiency virus long terminal repeat.
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Epstein-Barr 病毒立即早期基因产物反式激活人类免疫缺陷病毒长末端重复序列的基因表达。
DOI：
10.1073/pnas.85.5.1652
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发表时间：
1988
影响因子：
11.1
通讯作者：
Pagano,J
中科院分区：
文献类型：
--
作者：
Kenney,S;Kamine,J;Markovitz,D;Fenrick,R;Pagano,J
获得性免疫缺陷综合征患者经常合并感染EB病毒（EBV）。在这份报告中，我们证明，EBV立即早期基因产物，BamHI MLF 1，刺激表达的细菌氯霉素乙酰转移酶（CAT）基因连接到人类免疫缺陷病毒（HIV）启动子。EBV反式激活所必需的HIV启动子序列不包括tat应答序列。此外，与以前研究的其他疱疹病毒反式激活因子相反，EBV BamHI MLF 1基因产物似乎部分通过转录后机制发挥作用，因为它增加pHIV-CAT蛋白活性多于增加HIV-CAT mRNA。这种EBV基因产物激活HIV基因表达的能力可能对同时感染两种病毒的人产生生物学后果。
Acquired immunodeficiency syndrome patients are frequently coinfected with Epstein-Barr virus (EBV). In this report, we demonstrate that an EBV immediate-early gene product, BamHI MLF1, stimulates expression of the bacterial chloramphenicol acetyltransferase (CAT) gene linked to the human immunodeficiency virus (HIV) promoter. The HIV promoter sequences necessary for trans-activation by EBV do not include the tat-responsive sequences. In addition, in contrast to the other herpesvirus trans-activators previously studied, the EBV BamHI MLF1 gene product appears to function in part by a posttranscriptional mechanism, since it increases pHIV-CAT protein activity more than it increases HIV-CAT mRNA. This ability of an EBV gene product to activate HIV gene expression may have biologic consequences in persons coinfected with both viruses.
EB 病毒与人类疾病
影响因子：
2.7
作者：
Paul H. Levine;D. Ablashi;M. Nonoyama;G. R. Pearson;R. Glaser
通讯作者：
R. Glaser