Intranasal oxytocin administration impacts the acquisition and consolidation of trauma-associated memories: a double-blind randomized placebo-controlled experimental study in healthy women.
Intranasal oxytocin administration impacts the acquisition and consolidation of trauma-associated memories: a double-blind randomized placebo-controlled experimental study in healthy women.
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DOI：
10.1038/s41386-021-01247-4
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发表时间：
2022-04
期刊：
影响因子：
--
通讯作者：
Roepke S
中科院分区：
文献类型：
--
作者：
Schultebraucks K;Maslahati T;Wingenfeld K;Hellmann-Regen J;Kraft J;Kownatzki M;Behnia B;Ripke S;Otte C;Roepke S
侵入性记忆是创伤后应激障碍（PTSD）的标志性症状，催产素与侵入性记忆的形成有关。本研究探讨了催产素如何影响创伤相关记忆的获得和巩固，以及这些影响是否受到个体神经生物学和遗传差异的影响。在这项随机、双盲、安慰剂对照的研究中，220名健康女性在观看唤起侵入性记忆的创伤电影范式之前，要么接受单剂量的鼻内催产素，要么接受安慰剂。我们使用“一般随机森林”机器学习方法来检验去甲肾上腺素能和下丘脑-垂体-肾上腺轴活性的差异、精神疾病的多基因风险和催产素受体的遗传多态性是否影响催产素对侵入性记忆的获得和巩固的作用。催产素诱导的侵入性记忆明显多于安慰剂（t(188.33) = 2.12, p = 0.035, Cohen’s d = 0.30, 95% CI 0.16-0.44）。正如假设的那样，我们发现催产素对侵入性记忆的影响受到生物学协变量的影响，如唾液皮质醇、心率变异性和创伤后应激障碍多基因风险评分。在泊松回归中纳入了与催产素对侵入性记忆影响最相关的五个因素，结果表明，在暴露于创伤片应激源后，创伤后应激障碍和重性抑郁症的多基因负荷增加与报告的入侵次数增加直接相关。这些结果表明，鼻内催产素增强了侵入性记忆的获取和巩固，这种效果是由神经生物学和遗传因素调节的。试验注册：NCT03031405。
Intrusive memories are a hallmark symptom of post-traumatic stress disorder (PTSD) and oxytocin has been implicated in the formation of intrusive memories. This study investigates how oxytocin influences the acquisition and consolidation of trauma-associated memories and whether these effects are influenced by individual neurobiological and genetic differences. In this randomized, double-blind, placebo-controlled study, 220 healthy women received either a single dose of intranasal 24IU oxytocin or a placebo before exposure to a trauma film paradigm that solicits intrusive memories. We used a “general random forest” machine learning approach to examine whether differences in the noradrenergic and hypothalamic-pituitary-adrenal axis activity, polygenic risk for psychiatric disorders, and genetic polymorphism of the oxytocin receptor influence the effect of oxytocin on the acquisition and consolidation of intrusive memories. Oxytocin induced significantly more intrusive memories than placebo did (t(188.33) = 2.12, p = 0.035, Cohen’s d = 0.30, 95% CI 0.16–0.44). As hypothesized, we found that the effect of oxytocin on intrusive memories was influenced by biological covariates, such as salivary cortisol, heart rate variability, and PTSD polygenic risk scores. The five factors that were most relevant to the oxytocin effect on intrusive memories were included in a Poisson regression, which showed that, besides oxytocin administration, higher polygenic loadings for PTSD and major depressive disorder were directly associated with a higher number of reported intrusions after exposure to the trauma film stressor. These results suggest that intranasal oxytocin amplifies the acquisition and consolidation of intrusive memories and that this effect is modulated by neurobiological and genetic factors. Trial registration: NCT03031405.
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影响因子：
4.5
作者：
Athey, Susan;Tibshirani, Julie;Wager, Stefan
通讯作者：
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DOI：
10.1073/pnas.1510489113
发表时间：
2016-07-05
影响因子：
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影响因子：
10.6
作者：
Eckstein, Monika;Becker, Benjamin;Hurlemann, Rene
通讯作者：
Hurlemann, Rene