High dietary fat exacerbates weight gain and obesity in female liver fatty acid binding protein gene-ablated mice.
High dietary fat exacerbates weight gain and obesity in female liver fatty acid binding protein gene-ablated mice.
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DOI：
10.1007/s11745-009-3379-2
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发表时间：
2010-02
期刊：
影响因子：
1.9
通讯作者：
Schroeder, Friedhelm
中科院分区：
文献类型：
--
作者：
Atshaves, Barbara P.;McIntosh, Avery L.;Storey, Stephen M.;Landrock, Kerstin K.;Kier, Ann B.;Schroeder, Friedhelm
由于肝脏脂肪酸结合蛋白（L-FABP）促进培养的转染细胞和原代肝细胞中长链脂肪酸的摄取/氧化，因此预期L-FABP的丢失会加剧体重增加和/或肥胖，以响应高膳食脂肪。雄性和雌性野生型（WT）和L-FABP基因消融小鼠，成对喂养定义的等热量对照或高脂肪饮食12周，消耗等量的食物（重量和kcal）。无论饮食如何，雄性WT小鼠的体重增加速度都比雌性WT小鼠快。L-FABP基因切除增加雌性小鼠的体重增加多于雄性小鼠，高脂饮食加剧了这种影响。双发射X射线吸收测定法显示高脂肪喂养的雄性和雌性WT小鼠主要增加脂肪组织质量（FTM）。L-FABP基因切除增加了雌性小鼠的FTM，但对雄性小鼠没有影响-高脂饮食也加剧了这种影响。与此同时，L-FABP基因切除降低了喂食对照饮食的雄性和雌性小鼠的血清β-羟基丁酸酯，在高脂肪饮食中更是如此。因此，L-FABP基因去除降低了脂肪氧化，并使所有小鼠对全身FTM和LTM的体重增加敏感，其中在对照组与高脂肪喂养的雌性L-FABP缺失小鼠的FTM中观察到最大的增加。总之，这些结果表明L-FABP的损失加剧了响应于高膳食脂肪的体重增加和/或肥胖。
Since liver fatty acid binding protein (L-FABP) facilitates uptake/oxidation of long-chain fatty acids in cultured transfected cells and primary hepatocytes, loss of L-FABP was expected to exacerbate weight gain and/or obesity in response to high dietary fat. Male and female wild-type (WT) and L-FABP gene-ablated mice, pair-fed a defined isocaloric control or high fat diet for 12 weeks, consumed equal amounts of food by weight and kcal. Male WT mice gained weight faster than their female WT counterparts regardless of diet. L-FABP gene ablation enhanced weight gain more in female than male mice—an effect exacerbated by high fat diet. Dual emission X-ray absorptiometry revealed high-fat fed male and female WT mice gained mostly fat tissue mass (FTM). L-FABP gene ablation increased FTM in female, but not male, mice—an effect also exacerbated by high fat diet. Concomitantly, L-FABP gene ablation decreased serum β-hydroxybutyrate in male and female mice fed the control diet and, even more so, on the high-fat diet. Thus, L-FABP gene ablation decreased fat oxidation and sensitized all mice to weight gain as whole body FTM and LTM—with the most gain observed in FTM of control vs high-fat fed female L-FABP null mice. Taken together, these results indicate loss of L-FABP exacerbates weight gain and/or obesity in response to high dietary fat.
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影响因子：
3.9
作者：
Jolly, CA;Hubbell, T;Schroeder, F
通讯作者：
Schroeder, F
DOI：
10.1016/s1388-1981(99)00170-5
发表时间：
2000-01-03
影响因子：
4.8
作者：
Jolly, CA;Wilton, DC;Schroeder, F
通讯作者：
Schroeder, F
影响因子：
1.5
作者：
Mackie, John T.;Atshaves, Barbara P.;Kier, Ann B.
通讯作者：
Kier, Ann B.
DOI：
10.1152/ajpendo.00332.2001
发表时间：
2002-04-01
影响因子：
5.1
作者：
Burcelin, M;Crivelli, V;Thorens, B
通讯作者：
Thorens, B
影响因子：
15.9
作者：
Djouadi, F;Weinheimer, CJ;Kelly, DP
通讯作者：
Kelly, DP