Mechanical characterization and adhesive properties of a dental adhesive modified with a polymer antibiotic conjugate.
Mechanical characterization and adhesive properties of a dental adhesive modified with a polymer antibiotic conjugate.
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DOI：
10.1016/j.jmbbm.2022.105153
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发表时间：
2022-05
影响因子：
3.9
通讯作者：
Cheng, Chong
中科院分区：
文献类型：
--
作者：
Sabatini, Camila;Aguilar, Russell J.;Zhang, Ziwen;Makowka, Steven;Kumar, Abhishek;Jones, Megan M.;Visser, Michelle B.;Swihart, Mark;Cheng, Chong
关键词：
这项研究是我们小组最近工作的后续研究，展示了基于青霉素 V (PV) 的聚合物-抗生素缀合物 (PAC) 改性树脂的合成、释放和强抗菌特性。在这里，我们的目的是评估用 PV-PAC 改性的商用粘合剂树脂的机械、粘合和其他相关生物医学特性。 Single Bond Plus (SB+) 用含有 1.8 wt% 共轭 PV 的 PAC 进行改性。将粘合树脂粘合到提取的人磨牙的牙本质上，并添加修复树脂。从臼齿获得横截面积为 0.9 ± 0.1 mm (n = 20) 的梁，并在 24 小时和 4 个月时测试微拉伸粘合强度 (μTBS)。对于内聚强度，沙漏梁（10 × 2 × 1 mm；n = 10）评估极限拉伸强度（UTS），梁形样本（25×2×2 mm；n = 10）通过三点弯曲评估弯曲强度和模量（FS/FM），圆柱形样本（3 × 2 mm；n = 10）评估极限抗压强度（UCS）。对于表面显微硬度 (MH)，在 EtOH 挑战之前和之后评估圆柱形样本（3 × 2 mm；n = 6）。使用衰减全反射傅里叶变换红外 (ATR-FTIR) 光谱，根据粘合剂树脂固化前后 ~1637 cm−1 和 ~1608 cm−1 处峰之间吸光度比的变化来确定转化度 (DC)（5 × 1 mm；n = 6）。为了监测 28 天期间的吸水和扩散动力学，将样本 (5 × 1mm) 干燥、称重并储存在去离子水中。对照和 PV-PAC 改性粘合树脂在 24 小时和 4 个月时表现出相似的 μTBS； 4 个月后均显示数值下降（p = 0.001 和 0.004）。粘合树脂之间的 UTS、FS/FM 或 UCS 没有显着差异 (p<0.05)。 PV-PAC 粘合树脂的 MH 相对于对照显着降低 (p<0.001)。粘合剂树脂的DC值没有显着差异。虽然材料之间的吸附和溶解度没有差异，但 PV-PAC 改性粘合树脂的扩散系数高于对照 (p<0.001)。我们得出的结论是，将含有 1.8 wt% PV 的 PV-PAC 掺入粘合剂树脂中不会对其机械、粘合和物理性能产生不利影响，从而为具有长期抗菌特性和按需释放的材料提供了一个有前景的选择。
This study is a follow up investigation on recent work by our group demonstrating synthesis, release and strong antibacterial character of resins modified with penicillin V (PV)-based polymer-antibiotic conjugates (PACs). Here, we aimed to evaluate the mechanical, bonding, and other relevant biomedical properties of a commercial adhesive resin modified with PV-PAC. Single Bond Plus (SB+) was modified with PAC containing 1.8 wt% conjugated PV. Adhesive resins were bonded to dentin from extracted human molars and restorative resin added. Beams of cross-sectional area of 0.9 ± 0.1 mm (n = 20) were obtained from the molars and tested for micro-tensile bond strength (μTBS) at 24 h and 4 months. For cohesive strength, hourglass beams (10 × 2 × 1 mm; n = 10) were assessed for ultimate tensile strength (UTS), beam-shaped specimens (25×2×2 mm; n = 10) evaluated for flexural strength and modulus (FS/FM) via three-point bending, and cylindrical specimens (3 × 2 mm; n = 10) assessed for ultimate compressive strength (UCS). For surface micro-hardness (MH), cylindrical specimens (3 × 2 mm; n = 6) were assessed before and after an EtOH challenge. The degree of conversion (DC) (5 × 1 mm; n = 6) was determined based on changes in absorbance ratio between peaks at ~1637 cm−1 and ~1608 cm−1 before and after curing of adhesive resins using attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy. To monitor water uptake and diffusion kinetics over a 28-day period, specimens (5 × 1mm) were desiccated, weighed and stored in deionized water. Control and PV-PAC modified adhesive resins demonstrated similar μTBS at 24 h and 4 months; both showing decrease in values after 4 months (p = 0.001 and 0.004). No significant differences between adhesive resins were shown in UTS, FS/FM or UCS (p<0.05). MH of PV-PAC adhesive resin was significantly reduced relative to the control (p<0.001). The DC values of the adhesive resins were not significantly different. While sorption and solubility were no different between materials, the diffusion coefficient of PV-PAC modified adhesive resin was higher than the control (p<0.001). We conclude that incorporation of PV-PAC with 1.8 wt% PV into an adhesive resin does not adversely affect its mechanical, bonding, and physical properties, thus providing a promising option for materials with long-term antibacterial character and on-demand release.
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影响因子：
14
作者：
Ito, S;Hashimoto, M;Pashley, DH
通讯作者：
Pashley, DH
影响因子：
5
作者：
Ito, Shuichi;Hoshino, Tomohiro;Saito, Takashi
通讯作者：
Saito, Takashi
DOI：
10.5395/rde.2019.44.e28
发表时间：
2019-08-01
期刊：
Restorative dentistry & endodontics
影响因子：
--
作者：
da Cruz, Leonardo Bairrada Tavares;Oliveira, Marcelo Tavares;Lima, Adriano Fonseca
通讯作者：
Lima, Adriano Fonseca
影响因子：
5
作者：
Opdam, Niek J. M.;Bronkhorst, Ewald M.;Loomans, Bas A. C.
通讯作者：
Loomans, Bas A. C.
影响因子：
5
作者：
Hojati, Sara Tavassoli;Alaghemand, Homayoon;Atai, Mohammad
通讯作者：
Atai, Mohammad