New strigolactone mimics: structure-activity relationship and mode of action as germinating stimulants for parasitic weeds.
New strigolactone mimics: structure-activity relationship and mode of action as germinating stimulants for parasitic weeds.
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新的独脚金内酯模拟物：结构-活性关系和作为寄生杂草发芽刺激剂的作用方式。
DOI：
10.1016/j.bmcl.2013.07.004
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发表时间：
2013
影响因子：
2.7
通讯作者：
H. Bouwmeester
中科院分区：
文献类型：
--
作者：
B. Zwanenburg;S. Nayak;T. Charnikhova;H. Bouwmeester
己糖内酯是一种具有多种重要生物功能的新型植物激素。这封信是关于寄生杂草种子发芽的。天然SLs的结构过于复杂，难以合成。因此，人们积极寻找具有更简单结构和保留活性的SL类似物和模拟物。SL类似物都含有通过烯醇醚单元连接烯酮片段的d环。提出了一种双齿结合水和具有Ser-His-Asp催化三元组的α，β-水解酶水解SL类似物的新机制。新发现的SL模拟物只有在C-5上有合适离去基的d环。提出了一种SL模拟物的作用模式，现在提供了支持证据。正如预测的那样，d环C-4上多余的甲基阻碍了寄生杂草种子的萌发。
Strigolactones (SLs) are new plant hormones with varies important bio-functions. This Letter deals with germination of seeds of parasitic weeds. Natural SLs have a too complex structure for synthesis. Therefore, there is an active search for SL analogues and mimics with a simpler structure with retention of activity. SL analogues all contain the D-ring connected with an enone moiety through an enol ether unit. A new mechanism for the hydrolysis SL analogues involving bidentate bound water and an α,β-hydrolase with a Ser-His-Asp catalytic triad has been proposed. Newly discovered SL mimics only have the D-ring with an appropriate leaving group at C-5. A mode of action for SL mimics was proposed for which now supporting evidence is provided. As predicted an extra methyl group at C-4 of the D-ring blocks the germination of seeds of parasitic weeds.
影响因子：
9.2
作者：
Hamiaux, Cyril;Drummond, Revel S. M.;Snowden, Kimberley C.
通讯作者：
Snowden, Kimberley C.
影响因子：
4.1
作者：
K. Yoneyama;Xiaonan Xie;K. Yoneyama;Y. Takeuchi
通讯作者：
K. Yoneyama;Xiaonan Xie;K. Yoneyama;Y. Takeuchi
影响因子：
1.7
作者：
JOHNSON, AW;ROSEBERY, G;PARKER, C
通讯作者：
PARKER, C