Control of plasma sex steroid-binding protein (SBP) in the little brown bat: effects of thyroidectomy and treatment with L- and D-thyroxine on the induction of SBP in adult males.
Control of plasma sex steroid-binding protein (SBP) in the little brown bat: effects of thyroidectomy and treatment with L- and D-thyroxine on the induction of SBP in adult males.
复制标题
小棕蝠血浆性类固醇结合蛋白 (SBP) 的控制：甲状腺切除术以及 L-和 D-甲状腺素治疗对成年雄性 SBP 诱导的影响。
DOI：
10.1095/biolreprod33.5.1138
复制
发表时间：
1985
影响因子：
3.6
通讯作者：
Pratt,RD
中科院分区：
文献类型：
--
作者：
Damassa,DA;Gustafson,AW;Kwiecinski,GG;Pratt,RD
雄性小棕蝠是一种季节性繁殖的哺乳动物，在冬眠后的春季，它的血浆性类固醇结合蛋白(SBP)浓度会急剧增加。研究发现，从冬眠中过早唤醒的成年雄性蝙蝠，其血浆SBP滴度的升高与正常春季唤醒时观察到的水平相当。为了评价甲状腺在控制该物种SBP中的作用，每隔一周测定一次成年雄性蝙蝠的血浆SBP浓度，这些成年雄性蝙蝠在冬眠后接受甲状旁腺切除(TRX)或假手术(SHAM)。在觉醒后的第一周内，假雄鼠的血浆SBP滴度显著升高，到3周时已经达到冬眠对照组的20倍。相反，TRX动物的血浆SBP值在觉醒后并没有显著增加，但在整个实验过程中一直保持在较低的基础水平。经L或D-甲状腺素微丸植入后，可完全恢复被Trx阻断的SBP升高。在雄性蝙蝠中，TRX还阻止了性附腺的正常萎缩，并导致了血浆睾酮浓度上升的减弱。TRX的这些效应也可以通过甲状腺激素的治疗来预防。因此，甲状腺似乎在控制小棕蝠的SBP上升中起着重要作用，并可能是调节该物种生殖功能的重要因素。
The male little brown bat is a seasonally reproductive mammal that exhibits dramatic increases in plasma concentrations of sex steroid-binding protein (SBP) in the spring, following arousal from hibernation. Adult male bats, aroused prematurely from hibernation, were found to exhibit increases in plasma SBP titers that were comparable to those observed during normal spring arousal. To evaluate the role of the thyroid gland in the control of SBP in this species, plasma SBP concentrations were determined at weekly intervals in adult male bats that were either thyroparathyroidectomized (TRX) or sham operated (SHAM) after arousal from hibernation. Plasma SBP titers in SHAM males increased markedly within the first week after arousal and by 3 wk had reached levels 20-fold higher than those measured in hibernating controls. In contrast, plasma SBP values in the TRX animals did not increase significantly following arousal but were maintained at low basal levels throughout the experiment. The postarousal rise in SBP, which was blocked by TRX, was completely restored by implantation of either L- or D-thyroxine pellets. In male bats, TRX also hindered the normal postarousal atrophy of the sex accessory glands and resulted in attenuation of the postarousal increases in plasma testosterone concentrations. These effects of TRX were also prevented by treatment with thyroxine. Thus, the thyroid appears to play a significant role in the control of the postarousal rise of SBP in the little brown bat and may be an important factor in the regulation of reproductive function in this species.
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人血清性类固醇结合蛋白（SBP）的过滤测定
影响因子：
3.5
作者：
K. Mickelson;P. Pétra
通讯作者：
P. Pétra
睾酮结合球蛋白与雄激素未能抑制长期去势成年雄性恒河猴（Macaca mulatta）血清促性腺激素浓度之间的关系。
DOI：
10.1016/0022-4731(81)90055-8
发表时间：
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影响因子：
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作者：
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DOI：
10.1016/0022-4731(83)91111-1
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期刊：
Journal of steroid biochemistry
影响因子：
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DOI：
10.1210/jcem-59-4-806
发表时间：
1984
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
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作者：
Rosner,W;Aden,DP;Khan,MS
通讯作者：
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影响因子：
5.8
作者：
Dan Tulchinsky;Inder J. Chopra
通讯作者：
Inder J. Chopra