Role of cell-free network communication in alcohol-associated disorders and liver metastasis.
Role of cell-free network communication in alcohol-associated disorders and liver metastasis.
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DOI：
10.3748/wjg.v27.i41.7080
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发表时间：
2021-11-07
影响因子：
4.3
通讯作者：
McVicker BL
中科院分区：
文献类型：
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作者：
Kuracha MR;Thomas P;Tobi M;McVicker BL
酒精的异常使用是癌症进展和转移的主要因素。其作用机制包括酒精的全身效应以及沿着脑-肠-肝轴沿着的癌细胞和非癌细胞之间生物活性分子的交换。这种相互作用导致分子、细胞和生物学功能的变化，从而导致癌症进展。最近的研究已经检查了细胞外囊泡（EV）在癌症机制中的作用，除了它们作为诊断生物标志物的贡献。此外，EV正在成为病理生理学场景中的新型无细胞介质，包括酒精介导的肠道微生物组生态失调和纳米EV释放到循环系统中。有趣的是，癌症患者的EV富含癌基因、miRNA、脂质和糖蛋白，其向肝脏微环境的递送可能会因酒精的有害作用而增强。概念验证研究表明，酒精相关性肝病受到外来体影响，包括免疫反应改变，基质细胞重编程和细胞外基质重塑。此外，肝脏中酒精相关变化的高潮可能有助于增强癌症患者的肝转移和不良结局。本文综述了器官间外泌体通讯的许多方面，重点是EV在酒精相关疾病和癌症转移中的关系。EV货物和释放的潜在影响沿着多器官轴是高度相关的促进肿瘤发生机制和转移性疾病。假设EV靶向受体组织以启动促转移小生境的形成和癌症进展。转移性癌症中酒精相关机制的研究有望揭示对继发性恶性肿瘤生长相关因素的更好理解以及治疗干预的新方法。
The aberrant use of alcohol is a major factor in cancer progression and metastasis. Contributing mechanisms include the systemic effects of alcohol and the exchange of bioactive molecules between cancerous and non-cancerous cells along the brain-gut-liver axis. Such interplay leads to changes in molecular, cellular, and biological functions resulting in cancer progression. Recent investigations have examined the role of extracellular vesicles (EVs) in cancer mechanisms in addition to their contribution as diagnostic biomarkers. Also, EVs are emerging as novel cell-free mediators in pathophysiological scenarios including alcohol-mediated gut microbiome dysbiosis and the release of nanosized EVs into the circulatory system. Interestingly, EVs in cancer patients are enriched with oncogenes, miRNA, lipids, and glycoproteins whose delivery into the hepatic microenvironment may be enhanced by the detrimental effects of alcohol. Proof-of-concept studies indicate that alcohol-associated liver disease is impacted by the effects of exosomes, including altered immune responses, reprogramming of stromal cells, and remodeling of the extracellular matrix. Moreover, the culmination of alcohol-related changes in the liver likely contributes to enhanced hepatic metastases and poor outcomes for cancer patients. This review summarizes the numerous aspects of exosome communications between organs with emphasis on the relationship of EVs in alcohol-associated diseases and cancer metastasis. The potential impact of EV cargo and release along a multi-organ axis is highly relevant to the promotion of tumorigenic mechanisms and metastatic disease. It is hypothesized that EVs target recipient tissues to initiate the formation of prometastatic niches and cancer progression. The study of alcohol-associated mechanisms in metastatic cancers is expected to reveal a better understanding of factors involved in the growth of secondary malignancies as well as novel approaches for therapeutic interventions.
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研究血清和粪便中的microRNA-21表达水平是诊断结直肠癌的潜在非侵入性生物标志物。
影响因子：
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作者：
Bastaminejad S;Taherikalani M;Ghanbari R;Akbari A;Shabab N;Saidijam M
通讯作者：
Saidijam M
影响因子：
4.2
作者：
Chiba M;Kimura M;Asari S
通讯作者：
Asari S
影响因子：
11.2
作者：
Bobrie, Angelique;Krumeich, Sophie;Thery, Clotilde
通讯作者：
Thery, Clotilde
影响因子：
21.3
作者：
Costa-Silva B;Aiello NM;Ocean AJ;Singh S;Zhang H;Thakur BK;Becker A;Hoshino A;Mark MT;Molina H;Xiang J;Zhang T;Theilen TM;García-Santos G;Williams C;Ararso Y;Huang Y;Rodrigues G;Shen TL;Labori KJ;Lothe IM;Kure EH;Hernandez J;Doussot A;Ebbesen SH;Grandgenett PM;Hollingsworth MA;Jain M;Mallya K;Batra SK;Jarnagin WR;Schwartz RE;Matei I;Peinado H;Stanger BZ;Bromberg J;Lyden D
通讯作者：
Lyden D
DOI：
10.1038/mtna.2011.2
发表时间：
2012-02-07
期刊：
Molecular therapy. Nucleic acids
影响因子：
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作者：
通讯作者：
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