Dual core processing: MRB1 is an emerging kinetoplast RNA editing complex.
Dual core processing: MRB1 is an emerging kinetoplast RNA editing complex.
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DOI：
10.1016/j.pt.2012.11.005
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发表时间：
2013-02
影响因子：
9.6
通讯作者：
Lukeš J
中科院分区：
文献类型：
--
作者：
Hashimi H;Zimmer SL;Ammerman ML;Read LK;Lukeš J
Our understanding of kinetoplastid RNA (kRNA) editing has centered on this paradigm: guide RNAs (gRNAs) provide a blueprint for uridine insertion/deletion into mitochondrial mRNAs by the RNA editing core complex (RECC). Yet the characterization of constituent subunits of the mitochondrial RNA-binding complex 1 (MRB1) implies that it too is vital to the editing process. The recently elucidated MRB1 architecture will be instrumental in putting functional data from individual subunits into context. Our model depicts two functions for MRB1: mediating multi-round kRNA editing by coordinating the exchange of multiple gRNAs required by RECC to edit lengthy regions of mRNAs, and then linking kRNA editing with other RNA processing events.
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影响因子：
4.5
作者：
Ammerman, Michelle L.;Presnyak, Vladimir;Read, Laurie K.
通讯作者：
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影响因子：
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DOI：
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发表时间：
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影响因子：
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通讯作者：
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作者：
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通讯作者：
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