Inflammation and pro-resolution inflammation after hepatobiliary surgery.
Inflammation and pro-resolution inflammation after hepatobiliary surgery.
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DOI：
10.1186/s12957-017-1220-6
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发表时间：
2017-08-10
影响因子：
3.2
通讯作者：
Aloia T
中科院分区：
文献类型：
--
作者：
Cata JP;Velasquez JF;Ramirez MF;Vauthey JN;Gottumukkala V;Conrad C;Kim BJ;Aloia T
围手术期炎症反应的程度在手术结果中起作用。然而，很少有研究探讨了在手术背景下炎症消退的机制。在这里，我们描述了接受肿瘤肝切除术的患者中白细胞介素-6、皮质醇、脂氧素A4和消退素D的时间动力学。所有患者均签署了书面知情同意书。在术前和术后第1、3和5天的早晨收集人口统计学和围手术期手术数据，沿着血液样本。测定血浆中的白细胞介素-6、皮质醇、脂氧素-A4和消退素D。P值< 0.05被认为具有统计学显著性。41例患者入组研究。结直肠转移性疾病的肝切除术是最常见的手术。白细胞介素-6的血浆浓度在手术后第1天最高，并且在术后第1天仍高于基线。14例（24%）患者发生术后并发症。术后第1天皮质醇浓度增加。脂氧素A4和消退素D的浓度在术后第1天最低。与肝胆外科手术相关的炎症反应与脂氧素A4和消退素D的低循环浓度相关，这以相反的方式反映了白细胞介素6和皮质醇的动力学。 NCT01438476
The magnitude of the perioperative inflammatory response plays a role in surgical outcomes. However, few studies have explored the mechanisms of the resolution of inflammation in the context of surgery. Here, we described the temporal kinetics of interleukin-6, cortisol, lipoxin A4, and resolvin D in patients who underwent oncologic liver resections. All patients gave written informed consent. Demographic and perioperative surgical data were collected, along with blood samples, before surgery and on the mornings of postoperative days 1, 3, and 5. Interleukin-6, cortisol, lipoxin-A4, and resolvin D were measured in plasma. A P value < 0.05 was considered statistically significant. Forty-one patients were included in the study. Liver resection for colorectal metastatic disease was the most commonly performed surgery. The plasma concentrations of interleukin-6 were highest on day 1 after surgery and remained higher than the baseline up to postoperative day 1. Postoperative complications occurred in 14 (24%) patients. Cortisol concentrations spiked on postoperative day 1. The concentrations of lipoxin A4 and resolvin D were lowest on day 1 after surgery. The inflammatory response associated with hepatobiliary surgery is associated with low circulating concentrations of lipoxin A4 and resolvin D that mirror, in an opposite manner, the kinetics of interleukin 6 and cortisol. NCT01438476
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DOI：
10.1016/j.jvir.2013.02.015
发表时间：
2013-08
期刊：
Journal of vascular and interventional radiology : JVIR
影响因子：
--
作者：
Erinjeri JP;Thomas CT;Samoilia A;Fleisher M;Gonen M;Sofocleous CT;Thornton RH;Siegelbaum RH;Covey AM;Brody LA;Alago W Jr;Maybody M;Brown KT;Getrajdman GI;Solomon SB
通讯作者：
Solomon SB
影响因子：
5.3
作者：
Gutierrez, Absalon D.;Sathyanarayana, Padma;Bajaj, Mandeep
通讯作者：
Bajaj, Mandeep
影响因子：
37.8
作者：
BREZINSKI, DA;NESTO, RW;SERHAN, CN
通讯作者：
SERHAN, CN
专门的促解决介质：感染和炎症的内源性调节剂。
DOI：
10.1038/nri.2015.4
发表时间：
2016-01
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Basil MC;Levy BD
通讯作者：
Levy BD
影响因子：
9
作者：
Lahiri, Rajiv;Derwa, Yannick;Alazawi, William
通讯作者：
Alazawi, William