Silent corticotroph adenomas.

Silent corticotroph adenomas.
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DOI:
10.1007/s11102-014-0624-3
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发表时间:
2015-04
期刊:
影响因子:
3.8
通讯作者:
Cooper, Odelia
Cooper, Odelia
中科院分区:
医学2区
文献类型:
--
作者:
Cooper, Odelia

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无症状性促皮质腺瘤(SCAs)占所有促皮质腺瘤的20%,无功能腺瘤(NFAs)占3-19%。由于他们没有表现出临床或生化高皮质醇症,在切除的肿瘤组织病理检查显示ACTH阳性表达后被诊断。虽然术前特征与NFAs相似,但SCAs可能有更多的海绵窦侵犯。此外,SCAs患者往往比NFAs患者有更频繁和更早的复发,往往需要多次手术和其他方式的治疗。本文综述了SCAs的发病率、发病机制和临床行为。在PubMed上进行了系统的文献综述,以获取有关无症状性皮质性腺瘤的信息。本文介绍了SCAs患者的流行病学、发病机制、病理、临床表现、术后病程和管理方面的最新发现。这篇综述强调了严格监测sca患者复发和垂体功能减退的必要性。
Silent corticotroph adenomas (SCAs) comprise 20% of all corticotroph adenomas and 3-19% of nonfunctioning adenomas (NFAs). As they do not manifest clinical or biochemical hypercortisolism, they are diagnosed after pathologic examination of resected tumor tissue demonstrates positive ACTH expression. While preoperative features are similar to those of NFAs, SCAs may have more cavernous sinus invasion. Further, patients with SCAs tend to have more frequent and earlier recurrences than those with NFAs, often necessitating multiple surgeries and other modalities of treatment. This article reviews the incidence, pathogenesis, and clinical behavior of SCAs. A systematic literature review was performed using PubMed for information regarding silent corticotroph adenomas. Up to date findings regarding epidemiology, pathogenesis, pathology, clinical presentation, postoperative course, and management of patients with SCAs are presented. This review highlights the necessity of rigorous monitoring for recurrences and hypopituitarism in patients with SCAs.
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