Gap junctions and cancer: communicating for 50 years.
Gap junctions and cancer: communicating for 50 years.
复制标题
间隙连接和癌症：沟通50年。
DOI：
10.1038/nrc.2016.105
复制
发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
Laird DW
中科院分区：
文献类型：
--
作者：
Aasen T;Mesnil M;Naus CC;Lampe PD;Laird DW
50年前，人们发现肿瘤细胞缺乏电耦合，这导致了一种假设，即细胞间直接通讯的丧失通常与癌症的发生和进展有关。随后的研究将这种现象与连接蛋白组成的间隙连接联系起来。虽然许多研究支持连接蛋白是肿瘤抑制因子的观点，但最近的证据表明，在某些肿瘤类型中，它们可能通过连接和非连接信号通路促进肿瘤进展的特定阶段。这篇时间轴文章强调了连接间隙连接与癌症的里程碑，并强调了该领域中重要的未回答的问题，争议和治疗机会。
Fifty years ago, tumour cells were found to lack electrical coupling, leading to the hypothesis that loss of direct intercellular communication is commonly associated with cancer onset and progression. Subsequent studies linked this phenomenon to gap junctions composed of connexin proteins. While many studies support the notion that connexins are tumour suppressors, recent evidence suggests that, in some tumour types, they may facilitate specific stages of tumour progression through both junctional and non-junctional signalling pathways. This Timeline article highlights the milestones connecting gap junctions to cancer, and underscores important unanswered questions, controversies and therapeutic opportunities in the field.
DOI：
10.1083/jcb.108.3.1053
发表时间：
1989-03
期刊：
The Journal of cell biology
影响因子：
--
作者：
Mehta PP;Bertram JS;Loewenstein WR
通讯作者：
Loewenstein WR