One platform, five brands: how nature cuts the cost on riboswitches.
One platform, five brands: how nature cuts the cost on riboswitches.
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一个平台，五个品牌：大自然如何降低核糖开关的成本。
DOI：
10.1016/j.jmb.2013.03.036
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发表时间：
2013
影响因子：
5.6
通讯作者：
Ke,Ailong
中科院分区：
文献类型：
--
作者：
Grigg,JasonC;Ke,Ailong
核糖开关响应细胞中代谢物浓度的变化而顺式调节基因表达。自从2002年发现了黄素单胞苷肽[1]、[2]和焦磷酸硫胺素[1]、[3]传感核糖开关以来，已经鉴定了20多类代谢物响应核糖开关，主要控制细菌中的必需代谢或毒力基因。核糖开关通常存在于mRNA的5′非翻译区，它们通常通过调节过早的转录终止或翻译起始来控制表达。一些核糖开关另外控制mRNA周转4或Rho依赖性终止。[5]不管它们的调节机制如何，模块化核糖开关结构由适体结构域（配体结合）和效应子结构域（调节）组成。配体与适体结构域的结合稳定了替代结构，并诱导效应结构域开关以开启或关闭基因表达。核糖开关提供了一种有效和快速的手段来响应细胞中不断变化的代谢条件。
Riboswitches regulate gene expression in cis in response to changing metabolite concentrations in cells. Since flavin mononucleotide [1],[2] and thiamine pyrophosphate [1],[3] sensing riboswitches were discovered in 2002, more than 20 classes of metabolite-responsive riboswitches have been identified, primarily controlling essential metabolic or virulence genes in bacteria. Riboswitches are typically found in the mRNA 5′ untranslated region where they control expression usually by regulating premature transcription termination or translation initiation. Some riboswitches additionally control mRNA turnover 4 or Rho-dependent termination. 5 Regardless of their regulatory mechanism, the modular riboswitch structure is composed of an aptamer domain (ligand binding) and an effector domain (regulation). Ligand binding to the aptamer domain stabilizes an alternate structure and induces an effector domain switch to turn gene expression on or off. Riboswitches offer an efficient and rapid means to respond to changing metabolic conditions in a cell.
影响因子：
6.1
作者：
Batey, Robert T.
通讯作者：
Batey, Robert T.
影响因子：
5.6
作者：
Stoddard, Colby D.;Widmann, Jeremy;Trausch, Jeremiah J.;Marcano-Velazquez, Joan G.;Knight, Rob;Batey, Robert T.
通讯作者：
Batey, Robert T.