Pre-reproductive maternal enrichment influences rat maternal care and offspring developmental trajectories: behavioral performances and neuroplasticity correlates.
Pre-reproductive maternal enrichment influences rat maternal care and offspring developmental trajectories: behavioral performances and neuroplasticity correlates.
复制标题
DOI：
10.3389/fnbeh.2015.00066
复制
发表时间：
2015
影响因子：
3
通讯作者：
Petrosini L
中科院分区：
文献类型：
--
作者：
Cutuli D;Caporali P;Gelfo F;Angelucci F;Laricchiuta D;Foti F;De Bartolo P;Bisicchia E;Molinari M;Farioli Vecchioli S;Petrosini L
环境丰富（EE）是一种广泛使用的范式，用于研究复杂刺激对大脑和行为的影响。在这里，我们研究了雌性大鼠在生殖前接触 EE 是否会影响其母性护理和后代认知表现。为了实现这一目标，从断奶到繁殖年龄的丰富雌性（EF）都在丰富的环境中饲养。在标准条件下饲养的雌性用作对照。 2.5 个月大时，所有雌性都与它们的后代在标准条件下交配和饲养。对哺乳期母鼠的产妇护理行为和筑巢活动进行了评估。他们的雄性幼崽也在出生后的不同日子（pnd）进行了行为评估。测量大脑 BDNF、reelin 和成人海马神经发生水平作为神经可塑性的生化相关性。由于 EF 的舔舐、蹲伏和筑巢活动水平较高，因此表现出比对照组更复杂的母性护理。此外，与对照组相比，它们的后代表现出更高的辨别能力（母体气味偏好 T 迷宫，pnd 10）和空间表现（莫里斯水迷宫，pnd 45；有物体的开放场地，pnd 55）表现，而社交能力没有差异（社交能力测试，pnd 35）。幼仔断奶时 EF 额叶皮质中的 BDNF 水平以及第 21 和 55 岁的后代海马中的 BDNF 水平有所增加。未发现后代 reelin 和成年海马神经发生水平存在差异。总之，我们的研究表明，生殖前母体丰富对雌性大鼠的母体护理和后代的认知发展产生积极影响，从而证明 EE 益处的跨代传递与增强 BDNF 诱导的神经可塑性有关。
Environmental enrichment (EE) is a widely used paradigm for investigating the influence of complex stimulations on brain and behavior. Here we examined whether pre-reproductive exposure to EE of female rats may influence their maternal care and offspring cognitive performances. To this aim, from weaning to breeding age enriched females (EF) were reared in enriched environments. Females reared in standard conditions were used as controls. At 2.5 months of age all females were mated and reared in standard conditions with their offspring. Maternal care behaviors and nesting activity were assessed in lactating dams. Their male pups were also behaviorally evaluated at different post-natal days (pnd). Brain BDNF, reelin and adult hippocampal neurogenesis levels were measured as biochemical correlates of neuroplasticity. EF showed more complex maternal care than controls due to their higher levels of licking, crouching and nest building activities. Moreover, their offspring showed higher discriminative (maternal odor preference T-maze, pnd 10) and spatial (Morris Water Maze, pnd 45; Open Field with objects, pnd 55) performances, with no differences in social abilities (Sociability test, pnd 35), in comparison to controls. BDNF levels were increased in EF frontal cortex at pups' weaning and in their offspring hippocampus at pnd 21 and 55. No differences in offspring reelin and adult hippocampal neurogenesis levels were found. In conclusion, our study indicates that pre-reproductive maternal enrichment positively influences female rats' maternal care and cognitive development of their offspring, demonstrating thus a transgenerational transmission of EE benefits linked to enhanced BDNF-induced neuroplasticity.
登录
查看更多内容
影响因子：
3.4
作者：
Biamonte, Filippo;Latini, Laura;Keller, Flavio
通讯作者：
Keller, Flavio
影响因子：
5.3
作者：
Farioli-Vecchioli S;Ceccarelli M;Saraulli D;Micheli L;Cannas S;D'Alessandro F;Scardigli R;Leonardi L;Cinà I;Costanzi M;Mattera A;Cestari V;Tirone F
通讯作者：
Tirone F
DOI：
10.1523/jneurosci.5057-08.2009
发表时间：
2009-02-04
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Arai JA;Li S;Hartley DM;Feig LA
通讯作者：
Feig LA
DOI：
10.1073/pnas.95.9.5335
发表时间：
1998-04-28
影响因子：
11.1
作者：
Caldji, C;Tannenbaum, B;Meaney, MJ
通讯作者：
Meaney, MJ
影响因子：
10.6
作者：
Champagne, Frances A.;Meaney, Michael J.
通讯作者：
Meaney, Michael J.