Role of circadian rhythms in pathogenesis of acute CNS injuries: Insights from experimental studies.
Role of circadian rhythms in pathogenesis of acute CNS injuries: Insights from experimental studies.
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DOI：
10.1016/j.expneurol.2022.114080
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发表时间：
2022-07
影响因子：
5.3
通讯作者：
Whittemore, Scott R.
中科院分区：
文献类型：
--
作者：
Hetman, Michal;Slomnicki, Lukasz P.;Hodges, Emily R.;Ohri, Sujata Saraswat;Whittemore, Scott R.
关键词：
许多生理过程都显示出昼夜节律的振荡，这对生物体的动态平衡至关重要。因此，这种节律性的破坏导致了各种慢性病的发生。中枢神经系统急性损伤的发生、严重程度和解决也可能受到昼夜节律和/或抗节律干扰的调节。从机制上讲，昼夜节律性源于时钟途径转录因子内在的昼夜节律活动，这些转录因子在大约24小时的周期中调节基因的表达。此外，它们的活动被外部时间线索同步，产生24小时的昼夜节律。昼夜节律的致病意义可以通过确定(I)自然的昼夜/昼夜时间，(Ii)扰乱节律性的时间提示操作，(Iii)靶向时钟途径的药物，以及(Iv)基因操作来灭活时钟途径的关键介质的影响来实验测试。这篇综述总结了所有这些策略的新证据，这些证据支持昼夜节律在中风、创伤性脑或脊髓损伤、癫痫持续状态和脑脊髓炎的啮齿动物模型中的作用。潜在的临床影响也被考虑，包括时间扰乱环境或一天中时间变化对治疗干预的反应的致病效应。控制良好的动物研究避免了可能使流行病学数据的解释复杂化的混杂因素的影响。它们还可以帮助确定调节中枢神经系统病理的昼夜节律的机制。
A wide range of physiological processes show circadian oscillations that are critical for organismal homeostasis. Consequently, disruption of such rhythmicity contributes to the pathogenesis of various chronic diseases. The occurrence, severity, and resolution of acute injuries to the central nervous system may also be modulated by circadian rhythms and/or anti-rhythmic disruptions. Mechanistically, circadian rhythmicity originates from the intrinsic circadian activity of the clock pathway transcription factors that regulate gene expression in a cycle of about 24 h. In addition, their activity is synchronized by external time cues including light, sleep or feeding to produce diurnal rhythms of 24 h. The pathogenic significance of circadian rhythms can be tested experimentally by determining the effects of (i) natural diurnal/circadian time, (ii) time cue manipulations that perturb the rhythmicity, (iii) drugs that target the clock pathway, and (iv) genetic manipulations to inactivate key mediators of the clock pathway. This review summarizes emerging evidence from all those strategies that supports a role of circadian and/or diurnal rhythms in rodent models of stroke, traumatic brain or spinal cord injury, status epilepticus and encephalomyelitis. Potential clinical implications are also considered, including pathogenic effects of the chronodisruptive environment or time of day variability in response to therapeutic interventions. Well-controlled animal studies avoid effects of confounding factors that may complicate interpretation of epidemiological data. They can also help to identify mechanisms that mediate the circadian modulation of a CNS pathology.
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DOI：
10.1146/annurev-pharmtox-010617-052645
发表时间：
2018-01-06
影响因子：
12.5
作者：
Chen Z;Yoo SH;Takahashi JS
通讯作者：
Takahashi JS
淋巴细胞昼夜节律的时钟控制淋巴结运输和适应性免疫反应。
影响因子：
32.4
作者：
Druzd D;Matveeva O;Ince L;Harrison U;He W;Schmal C;Herzel H;Tsang AH;Kawakami N;Leliavski A;Uhl O;Yao L;Sander LE;Chen CS;Kraus K;de Juan A;Hergenhan SM;Ehlers M;Koletzko B;Haas R;Solbach W;Oster H;Scheiermann C
通讯作者：
Scheiermann C
影响因子：
16.6
作者：
Banerjee, Subhashis;Wang, Yongjun;Burris, Thomas P.
通讯作者：
Burris, Thomas P.
影响因子：
5.1
作者：
Beker, Mustafa Caglar;Caglayan, Berrak;Kilic, Ertugrul
通讯作者：
Kilic, Ertugrul
影响因子：
2.6
作者：
Connolly LJ;Rajaratnam SMW;Murray JM;Spitz G;Lockley SW;Ponsford JL
通讯作者：
Ponsford JL