Home-based light therapy for fatigue following acquired brain injury: a pilot randomized controlled trial.
Home-based light therapy for fatigue following acquired brain injury: a pilot randomized controlled trial.
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获得性脑损伤后疲劳的家庭光疗法：一项试点随机对照试验。
DOI：
10.1186/s12883-021-02292-8
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发表时间：
2021-07-05
期刊：
影响因子：
2.6
通讯作者：
Ponsford JL
中科院分区：
文献类型：
--
作者：
Connolly LJ;Rajaratnam SMW;Murray JM;Spitz G;Lockley SW;Ponsford JL
疲劳和睡眠障碍是脑损伤后使人衰弱的问题，目前尚无成熟的治疗方法。基于灯箱发出的蓝光在减少 TBI 后的疲劳和白天嗜睡方面的功效，本研究评估了一种新型的家庭光干预在减轻疲劳、睡眠障碍、白天嗜睡和抑郁症状方面的功效，以及在受伤后提高精神运动警惕性和参与日常生产活动方面的功效。将暴露于动态光干预（治疗）与常规照明的影响进行了比较 （对照）在一项随机受试者内交叉试验中。结果包括疲劳（主要结果）、白天嗜睡、睡眠障碍、失眠症状、精神运动警惕性、情绪和活动水平。参与者（N = 24，M ± SDage = 44.3 ± 11.4）在 > 3个月前患有轻度至重度TBI或中风，并自我报告疲劳（疲劳严重程度 ≥ 4）。在 2 周基线之后，参与者以平衡顺序完成每个条件 2 个月，并进行 1 个月的随访。治疗包括白天富含蓝光的白光 (CCT > 5000 K) 和睡前 3 小时的蓝光消耗光 (< 3000 K)。随机效应混合模型分析显示，治疗期间简短疲劳量表上的疲劳没有显着更大的变化，但改善效果中等（p = .33，d = -0.42）。与对照组相比，治疗结束时睡眠障碍 (p = .004)、失眠症状 (p = .036)、反应时间 (p = .004) 和生产活动改善 (p = .005) 显着更大程度减少，且效应量较大 (d > 0.80)。其他结果的变化并不显着。这项试点研究为家庭动态光疗法提供了初步支持，以解决获得性脑损伤中与睡眠相关的症状。该试验于 2017 年 6 月 13 日在澳大利亚和新西兰临床试验注册处注册，网址：www.anzctr.org.au，ACTRN12617000866303。在线版本包含可在 10.1186/s12883-021-02292-8 获取的补充材料。
Fatigue and sleep disturbance are debilitating problems following brain injury and there are no established treatments. Building on demonstrated efficacy of blue light delivered via a lightbox in reducing fatigue and daytime sleepiness after TBI, this study evaluated the efficacy of a novel in-home light intervention in alleviating fatigue, sleep disturbance, daytime sleepiness and depressive symptoms, and in improving psychomotor vigilance and participation in daily productive activity, following injury The impact of exposure to a dynamic light intervention (Treatment) was compared to usual lighting (Control) in a randomized within-subject, crossover trial. Outcomes were fatigue (primary outcome), daytime sleepiness, sleep disturbance, insomnia symptoms, psychomotor vigilance, mood and activity levels. Participants (N = 24, M ± SDage = 44.3 ± 11.4) had mild-severe TBI or stroke > 3 months previously, and self-reported fatigue (Fatigue Severity Scale ≥ 4). Following 2-week baseline, participants completed each condition for 2 months in counter-balanced order, with 1-month follow-up. Treatment comprised daytime blue-enriched white light (CCT > 5000 K) and blue-depleted light (< 3000 K) 3 h prior to sleep. Random-effects mixed-model analysis showed no significantly greater change in fatigue on the Brief Fatigue Inventory during Treatment, but a medium effect size of improvement (p = .33, d = -0.42). There were significantly greater decreases in sleep disturbance (p = .004), insomnia symptoms (p = .036), reaction time (p = .004) and improvements in productive activity (p = .005) at end of Treatment relative to Control, with large effect sizes (d > 0.80). Changes in other outcomes were non-significant. This pilot study provides preliminary support for in-home dynamic light therapy to address sleep-related symptoms in acquired brain injury. This trial was registered with the Australian and New Zealand Clinical Trials Registry on 13 June 2017, www.anzctr.org.au, ACTRN12617000866303. The online version contains supplementary material available at 10.1186/s12883-021-02292-8.
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DOI：
10.1097/00002060-200105000-00003
发表时间：
2001-05-01
影响因子：
3
作者：
Fichtenberg, NL;Putnam, SH;Millard, AE
通讯作者：
Millard, AE
影响因子：
2.4
作者：
Jha, Amitabh;Weintraub, Alan;Gerber, Don
通讯作者：
Gerber, Don
影响因子：
2.8
作者：
Duffy, Jeanne F;Czeisler, Charles A
通讯作者：
Czeisler, Charles A
影响因子：
6.7
作者：
Anderson, J. L.;Glod, C. A.;Lockley, S. W.
通讯作者：
Lockley, S. W.
影响因子：
4.8
作者：
Bastien, Celyne H.;Vallieres, Annie;Morin, Charles M.
通讯作者：
Morin, Charles M.