Long term effects of radiation exposure on telomere lengths of leukocytes and its associated biomarkers among atomic-bomb survivors.
Long term effects of radiation exposure on telomere lengths of leukocytes and its associated biomarkers among atomic-bomb survivors.
复制标题
DOI：
10.18632/oncotarget.8801
复制
发表时间：
2016-06-28
期刊：
影响因子：
--
通讯作者：
Hayashi T
中科院分区：
文献类型：
--
作者：
Lustig A;Shterev I;Geyer S;Shi A;Hu Y;Morishita Y;Nagamura H;Sasaki K;Maki M;Hayashi I;Furukawa K;Yoshida K;Kajimura J;Kyoizumi S;Kusunoki Y;Ohishi W;Nakachi K;Weng NP;Hayashi T
电离辐射(IR)是细胞损伤的主要来源，细胞对IR的即时反应已被很好地描述。但IR对细胞功能的长期影响及其与衰老的关系尚不清楚。在这里，我们研究了二战期间广岛原子弹爆炸的幸存者在暴露50到68年(每人两个时间点)后对端粒长度和其他生物标志物的IR影响。我们发现白细胞的端粒长度与IR剂量呈负相关(p=0.008)，这种影响主要出现在较年轻的幸存者身上，尤其是那些12岁的幸存者(p=0.0004)。虽然在横断面数据中观察到了与剂量相关的端粒缩短随年龄的延迟，但11年后的纵向随访没有发现与IR暴露相关的端粒缩短速度随年龄的变化。此外，IR降低了未服用任何剂量的幸存者中观察到的端粒长度和选定的衰老生物标记物之间的相关性。这些指标包括尿酸代谢、细胞因子和血液T细胞计数。这些发现表明，IR对白细胞端粒长度的长期有害影响具有剂量和年龄依赖性，并随着年龄的增长对生物标记物的变化产生影响。
Ionizing radiation (IR) is a major source of cellular damage and the immediate cellular response to IR has been well characterized. But the long-term impact of IR on cell function and its relationship with aging are not known. Here, we examined the IR effects on telomere length and other biomarkers 50 to 68 years post-exposure (two time points per person) in survivors of the atomic bombing at Hiroshima during WWII. We found that telomere length of leukocytes was inversely correlated with the dose of IR (p=0.008), and this effect was primarily found in survivors who were exposed at younger ages; specifically those <12 years old (p=0.0004). Although a dose-related retardation of telomere shortening with age was observed in the cross-sectional data, longitudinal follow-up after 11 years did not show IR exposure-related alteration of the rate of telomere shortening with age. In addition, IR diminished the associations between telomere length and selected aging biomarkers that were observed in survivors with no dose. These included uric acid metabolism, cytokines, and blood T cell counts. These findings showed long-lasting detrimental effects of IR on telomere length of leukocytes in both dose- and age-at-exposure dependent manner, and on alterations of biomarkers with aging.
登录
查看更多内容
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
8.3
作者：
Benetos, A;Okuda, K;Aviv, A
通讯作者：
Aviv, A
影响因子：
50.3
作者：
Feldser, David M.;Greider, Carol W.
通讯作者：
Greider, Carol W.
DOI：
10.1042/cs20140481
发表时间：
2015-03
期刊：
Clinical science (London, England : 1979)
影响因子：
--
作者：
Lin Y;Damjanovic A;Metter EJ;Nguyen H;Truong T;Najarro K;Morris C;Longo DL;Zhan M;Ferrucci L;Hodes RJ;Weng NP
通讯作者：
Weng NP
影响因子：
3.5
作者：
Paulino, Arnold C.;Constine, Louis S.;Williams, Jacqueline P.
通讯作者：
Williams, Jacqueline P.