Understanding Immunity through the Lens of Disease Ecology.

Understanding Immunity through the Lens of Disease Ecology.
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DOI:
10.1016/j.it.2017.08.001
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发表时间:
2017-12
影响因子:
16.8
通讯作者:
Hedrick SM
Hedrick SM
中科院分区:
医学1区
文献类型:
--
作者:
Hedrick SM

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随着我们对免疫系统的描述越来越细致,我们可能会发现,无论多么成功,这种方法都不足以理解传染性病原体的传播、它们对疫苗治疗的敏感性以及人类的抗病能力。与严格的还原论实践作为表征大多数生物过程的一种手段相比,我建议通过关注疾病生态学,可以更清楚地了解致病宿主-寄生虫相互作用的进展和结果。
As we describe the immune system in ever more exquisite detail, we might find that no matter how successful, this approach will not be sufficient to understand the spread of infectious agents, their susceptibility to vaccine therapy, and human disease resistance. Compared with the strict reductionism practiced as a means of characterizing most biological processes, I propose that the progression and outcome of disease-causing host-parasite interactions will be more clearly understood through a focus on disease ecology.
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