A functional tandem-repeats polymorphism in the downstream of TERT is associated with the risk of nasopharyngeal carcinoma in Chinese population.
A functional tandem-repeats polymorphism in the downstream of TERT is associated with the risk of nasopharyngeal carcinoma in Chinese population.
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TERT下游的功能性串联重复多态性与中国人群鼻咽癌的风险相关。
DOI：
10.1186/1741-7015-9-106
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发表时间：
2011-09-20
期刊：
影响因子：
9.3
通讯作者：
Zhou G
中科院分区：
文献类型：
--
作者：
Zhang Y;Zhang H;Zhai Y;Wang Z;Ma F;Wang H;Li P;Zhang Y;Yu L;Cui Y;He F;Zhou G
端粒酶逆转录酶（TERT）的表达和端粒酶活性的增高在鼻咽癌中是常见的。最近，一个可变的串联重复序列多态性，MNS 16 A，位于下游区域的端粒酶基因，被确定和报告有影响的端粒酶活性和端粒酶的表达。我们研究了功能性MNS 16 A是否与中国人群中NPC发生或进展的风险有关。我们采用PCR方法对855例鼻咽癌患者和1036例正常对照进行了MNS 16A基因多态性的病例对照研究，并通过将243或272 bp的DNA条带分类为短（S）等位基因和302或333 bp的DNA条带分类为长（L）等位基因来确定基因型。用Logistic回归分析鼻咽癌的遗传易感性。MNS16A基因型与鼻咽癌的进展无关。然而，携带S等位基因（SL + SS基因型）的个体与携带LL基因型的个体相比，鼻咽癌发生的风险显著降低（比值比（OR）= 0. 05）。71，95%置信区间（CI）= 0。52比0 96，P = 0。025）。采用免疫组化法检测鼻咽癌组织中SL基因型携带者的TERT表达低于LL基因型携带者（P = 0. 05）。035）。我们的研究表明，TERTMNS16A基因多态性可能与中国人群鼻咽癌的发病风险有关。
Increases in human telomerase reverse transcriptase (TERT) expression and telomerase activity are frequently seen in nasopharyngeal carcinoma (NPC). Recently, a variable tandem-repeats polymorphism, MNS16A, located in the downstream region of the TERT gene, was identified and reported to have an effect on TERT expression and telomerase activity. We examined whether the functional MNS16A was related to the risk of occurrence or progression of NPC in the Chinese population. We genotyped the MNS16A polymorphism in a case-control study of 855 patients with NPC and 1036 cancer-free controls using PCR, and determined genotype by classifying the DNA band of 243 or 272 base pairs (bp) as the short (S) allele and 302 or 333 bp as the long (L) allele. The genetic associations with the risk of NPC were analyzed by logistic regression. The MNS16A genotype was not associated with the progression of NPC. However, individuals carrying the S alleles (SL + SS genotype) had a significantly reduced risk of NPC occurrence compared with those carrying the LL genotype (odds ratio (OR) = 0. 71, 95% confidence interval (CI) = 0. 52 to 0. 96, P = 0. 025). Using a immunohistochemical assay on the NPC tissues, the SL genotype carriers were found to have lower TERT expression than the LL genotype carriers (P = 0. 035). Our study indicates that the TERT MNS16A polymorphism may contribute to the risk of NPC onset in Chinese population.
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影响因子：
45.3
作者：
Wang, L;Wei, QY;Bondy, ML
通讯作者：
Bondy, ML
DOI：
10.1002/hed.20833
发表时间：
2008-07
影响因子：
2.9
作者：
Chou, Josephine;Lin, Yu-Ching;Kim, Jae;You, Liang;Xu, Zhidong;He, Biao;Jablons, David M.
通讯作者：
Jablons, David M.
影响因子：
8.8
作者：
Cheng, RYS;Yuen, PW;Nicholls, JM;Zheng, Z;Wei, W;Sham, JST;Yang, XH;Cao, L;Huang, DP;Tsao, SW
通讯作者：
Tsao, SW
影响因子：
5
作者：
Deng, Yibin;Chang, Sandy
通讯作者：
Chang, Sandy
影响因子：
6.4
作者：
Andersson, Ulrika;Osterman, Pia;Malmer, Beatrice
通讯作者：
Malmer, Beatrice