Nasopharyngeal carcinoma--review of the molecular mechanisms of tumorigenesis.
Nasopharyngeal carcinoma--review of the molecular mechanisms of tumorigenesis.
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DOI：
10.1002/hed.20833
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发表时间：
2008-07
影响因子：
2.9
通讯作者：
Jablons, David M.
中科院分区：
文献类型：
--
作者：
Chou, Josephine;Lin, Yu-Ching;Kim, Jae;You, Liang;Xu, Zhidong;He, Biao;Jablons, David M.
鼻咽癌（NPC）是一种头颈部癌症，在世界大部分地区很少见，但在某些地理区域很常见，如南亚。虽然环境因素和遗传易感性在鼻咽癌发病中起重要作用，但Epstein-Barr病毒尤其与导致鼻咽癌的分子异常有关。细胞增殖通路如Akt通路、丝裂原活化蛋白激酶和Wnt通路上调。由于E-cadherin和β-catenin功能异常，细胞粘附受到损害。细胞周期异常是由于p16、cyclin D1和cyclin e等因子的失调，抗凋亡机制也上调。鼻咽癌特有的多种异常是新疗法的潜在靶点。
Nasopharyngeal carcinoma (NPC) is a head and neck cancer rare throughout most of the world but common in certain geographic areas, such as southern Asia. While environmental factors and genetic susceptibility play important roles in NPC pathogenesis, the Epstein–Barr virus in particular has been implicated in the molecular abnormalities leading to NPC. There is upregulation of cellular proliferation pathways such as the Akt pathway, mitogen-activated protein kinases, and the Wnt pathway. Cell adhesion is compromised due to abnormal E-cadherin and β-catenin function. Aberrations in cell cycle are due to dysregulation of factors such as p16, cyclin D1, and cyclin E. Anti-apoptotic mechanisms are also upregulated. There are multiple abnormalities unique to NPC that are potential targets for novel treatments.
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DOI：
10.1016/s0360-3016(97)00313-1
发表时间：
1997-08-01
影响因子：
7
作者：
Chow, E;Payne, D;Izard, MA
通讯作者：
Izard, MA
DOI：
10.1006/bbrc.1998.9256
发表时间：
1998-09-08
影响因子：
3.1
作者：
Bang, YJ;Kwon, JH;Yang, YC
通讯作者：
Yang, YC
影响因子：
2.9
作者：
CRABBE, T;OCONNELL, JP;DOCHERTY, AJP
通讯作者：
DOCHERTY, AJP
影响因子：
4.6
作者：
Cheung, HW;Ching, YP;Wang, XH
通讯作者：
Wang, XH
影响因子：
6.4
作者：
Chen, F;Liu, C;Ernberg, I
通讯作者：
Ernberg, I