Differential hypothalamic-pituitary-adrenal axis reactivity to psychological and physical stress.
Differential hypothalamic-pituitary-adrenal axis reactivity to psychological and physical stress.
复制标题
下丘脑-垂体-肾上腺轴对心理和身体压力的不同反应。
DOI：
10.1210/jcem.84.6.5746
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
P. Deuster
中科院分区：
文献类型：
--
作者：
Anita Singh;J. Petrides;P. Gold;G. Chrousos;P. Deuster
健康男性对运动应激表现出不同的下丘脑-垂体-肾上腺轴(HPA)反应，分为两组：高反应组(HR)和低反应组(LR)。本研究考察了HR对生理应激是否也表现出比LR更高的HPA对心理应激的反应。我们检测了14名HR和13名LR，根据他们在地塞米松预处理后对大强度运动的ACTH反应进行了分类。这两组人的年龄、身高、体重和健康水平相似。斯皮尔伯格特质焦虑量表上的特质焦虑得分没有差异。受试者接受了由访谈和心算组成的心理压力测试。这项测试提高了HR和LR的心率、血压以及血浆ACTH和皮质醇水平。在心理压力测试中，HR往往比LR有更高的心率和血压。在整个心理压力测试中，HR的ACTH反应高于LR，但并不显著。HR对心理压力的净积分皮质醇反应显著高于LR(P<；0.05)。这表明，HR的肾上腺皮质对ACTH是高度敏感和/或敏感的。我们的结论是，对运动压力高度敏感的男性也对心理压力高度敏感。
Healthy men exhibit a differential hypothalamic-pituitary-adrenal axis (HPA) response to exercise stress and fall into two groups: high responders (HR) and low responders (LR). The present study examined whether HR to physical stress also exhibit higher HPA reactivity to psychological stress than LR. We examined 14 HR and 13 LR classified based on their ACTH responses to high intensity exercise after pretreatment with dexamethasone. Both groups were of similar age, height, weight, and fitness level. Trait anxiety scores on the Spielberger Trait Anxiety Scale were not different. Subjects underwent a psychological stress test consisting of an interview and mental arithmetic. This test raised heart rate, blood pressure, and plasma ACTH and cortisol levels in both HR and LR. HR tended to have higher heart rates and blood pressures in anticipation of the psychological stress test than LR. ACTH responses of HR were higher, although not significantly, throughout the psychological stress test than LR. HR had a significantly (P < 0.05) greater net integrated cortisol response to the psychological stress than LR. This suggests that the adrenal cortexes of the HR are hypertropic and/or hypersensitive to ACTH. We conclude that men who are highly responsive to exercise stress are also highly responsive to psychological stress.
临床回顾 104：促肾上腺皮质激素 (ACTH) 和非 ACTH 介导的肾上腺皮质调节：神经和免疫输入。
DOI：
10.1210/jcem.84.5.5631
发表时间：
1999
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Bornstein,SR;Chrousos,GP
通讯作者：
Chrousos,GP
影响因子：
3.7
作者：
Sandra Sgoutas-Emch;J. Cacioppo;B. Uchino;W. Malarkey;D. Pearl;J. Kiecolt-Glaser;R. Glaser
通讯作者：
Sandra Sgoutas-Emch;J. Cacioppo;B. Uchino;W. Malarkey;D. Pearl;J. Kiecolt-Glaser;R. Glaser