Evaluation of the new Chinese Disseminated Intravascular Coagulation Scoring System in critically ill patients: A multicenter prospective study.
Evaluation of the new Chinese Disseminated Intravascular Coagulation Scoring System in critically ill patients: A multicenter prospective study.
复制标题
新的中国弥散性血管内凝血评分系统在危重患者中的评价：一项多中心前瞻性研究
DOI：
10.1038/s41598-017-09190-5
复制
发表时间：
2017-08-22
影响因子：
4.6
通讯作者：
Hu Y
中科院分区：
文献类型：
--
作者：
Wu Y;Luo L;Niu T;Han Y;Feng Y;Ding Q;Huang R;Zhang X;Feng J;Hou M;Peng J;Li Y;Zhou Y;Su L;Yang L;Zhou Z;Xue F;Gu J;Zhu T;Wang X;Deng J;Mei H;Hu Y
弥散性血管内凝血(DIC)是危重病患者常见的危及生命的并发症。DIC的诊断评分系统可以更及时、更准确地诊断DIC，例如国际血栓和止血学会(ISTH)、日本急性医学会(JAAM)和日本厚生福利省(JMHW)。这项研究前瞻性地评估了新提出的中国DIC评分系统，该系统在中国的18个中心进行，为期一年。受试者工作特征(ROC)曲线显示，在诊断DIC和预测28天全因死亡率方面，CDSS的ROC曲线下面积(AUC)大于ISTH和JAAM。在非感染性疾病中，CDSS对ISTH DIC的AUC也大于JMHW。CDSS的AUC均大于0.8，具有较高的敏感性和特异性。此外，CDSS评分是死亡率的独立预测因子(优势比，1.882；p <； 0.001)，并且可以反映疾病的严重程度(p <； 0.001，Spearman‘s等级与严重程度评分的相关性)。结论：CDSS对DIC有较好的诊断和预后价值，值得推广。
Disseminated intravascular coagulation (DIC) is a common life-threatening complication in critically ill patients. The diagnostic scoring systems of DIC enable a more prompt and accurate diagnosis of DIC, such as the International Society on Thrombosis and Haemostasis (ISTH), the Japanese Association for Acute Medicine (JAAM) and the Japanese Ministry of Health and Welfare (JMHW). This study prospectively evaluated the newly proposed Chinese DIC Scoring System (CDSS), which was conducted at 18 centers in China during a one-year period. Receiver operating characteristic (ROC) curves showed that, for diagnosis of DIC and for prediction of the 28-day all-cause mortality, the CDSS had larger areas under the ROC curve (AUCs) than the ISTH and the JAAM in different groups. The CDSS also had larger AUC than the JMHW for the ISTH DIC in non-infectious diseases. All of the AUCs of the CDSS were greater than 0.8, accompanied with both high sensitivity and high specificity. Furthermore, the CDSS score was an independent predictor of mortality (odds ratio, 1.882; p < 0.001), and could reflect the illness severity (p < 0.001 for Spearman’s rank correlations with the scores of severity). In conclusion, the CDSS is worthy of promotion with a better diagnostic and prognostic value for DIC.
登录
查看更多内容
影响因子：
7.5
作者：
Gando, Satoshi;Saitoh, Daizoh;Shimazaki, Shuji
通讯作者：
Shimazaki, Shuji
影响因子：
8.8
作者：
Vincent, JL;de Mendonca, A;Blecher, S
通讯作者：
Blecher, S
影响因子：
2.9
作者：
Aota, Takumi;Wada, Hideo;Katayama, Naoyuki
通讯作者：
Katayama, Naoyuki
影响因子：
8.8
作者：
Gando, S;Iba, T;Shimazaki, S
通讯作者：
Shimazaki, S
影响因子：
2.9
作者：
Hayakawa, Mineji;Gando, Satoshi;Hoshino, Hirokatsu
通讯作者：
Hoshino, Hirokatsu