Distinct Kinematic Adjustments over Multiple Timescales Accompany Locomotor Skill Development in Mice.
Distinct Kinematic Adjustments over Multiple Timescales Accompany Locomotor Skill Development in Mice.
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DOI：
10.1016/j.neuroscience.2021.05.002
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发表时间：
2021-07-01
期刊：
影响因子：
3.3
通讯作者：
Chase SM
中科院分区：
文献类型：
--
作者：
Nguyen KP;Sharma A;Gil-Silva M;Gittis AH;Chase SM
强健的运动对许多物种的生存至关重要，但人们对学习和保持有效运动的机制知之甚少。在小鼠中，测定运动学习的常见范例是旋转杆任务，其中小鼠学习在加速杆顶部保持平衡。然而，在这项任务中，学习的标准指标是下降延迟的改善，这对伴随运动学习的丰富的运动学调整几乎没有什么洞察力。在这项研究中，我们开发了一种称为RotaWheel的类似旋转杆的任务，其中使用高速摄像机跟踪爪子运动学的变化，因为小鼠学习停留在加速轮上。使用这个装置，我们发现，学习是伴随着刻板的进展，爪子运动学与早期，中期和后期的性能。在第一天，小鼠通过前爪向前摆动的定时暂停来提高它们的肢体间协调性。在接下来的几天里，老鼠减少了步幅，走得更短，更快。到训练的第二周，小鼠开始使用更可变的运动策略，其中跨爪选择连续的过冲或下冲来驱动车轮的向前和向后探索。总的来说，我们的研究结果表明，小鼠运动学习发生在不同的时间过程中，通过多种机制演变，并涉及不同的纠正措施。这些数据提供了洞察运动策略，伴随运动学习和建立一个实验平台，研究运动技能学习小鼠。
Robust locomotion is critical to many species’ survival, yet the mechanisms by which efficient locomotion is learned and maintained are poorly understood. In mice, a common paradigm for assaying locomotor learning is the rotarod task, in which mice learn to maintain balance atop of an accelerating rod. However, the standard metric for learning in this task is improvements in latency to fall, which gives little insight into the rich kinematic adjustments that accompany locomotor learning. In this study, we developed a rotarod-like task called the RotaWheel in which changes in paw kinematics are tracked using high-speed cameras as mice learn to stay atop an accelerating wheel. Using this device, we found that learning was accompanied by stereotyped progressions of paw kinematics that correlated with early, intermediate, and late stages of performance. Within the first day, mice sharpened their interlimb coordination using a timed pause in the forward swing of their forepaws. Over the next several days, mice reduced their stride length and took shorter, quicker steps. By the second week of training, mice began to use a more variable locomotor strategy, where consecutive overshoots or undershoots in strides were selected across paws to drive forward and backward exploration of the wheel. Collectively, our results suggest that mouse locomotor learning occurs through multiple mechanisms evolving over separate time courses and involving distinct corrective actions. These data provide insights into the kinematic strategies that accompany locomotor learning and establish an experimental platform for studying locomotor skill learning in mice.
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影响因子：
64.8
作者：
通讯作者：
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影响因子：
4.8
作者：
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通讯作者：
Bastian AJ
DOI：
10.1007/978-1-4614-5465-6_1
发表时间：
2013-01-01
期刊：
PROGRESS IN MOTOR CONTROL: NEURAL, COMPUTATIONAL AND DYNAMIC APPROACHES
影响因子：
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作者：
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通讯作者：
Krakauer, John W.
影响因子：
25
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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