Efficacy of the Common Elements Treatment Approach (CETA) for Unhealthy Alcohol Use Among Adults with HIV in Zambia: Results from a Pilot Randomized Controlled Trial.
Efficacy of the Common Elements Treatment Approach (CETA) for Unhealthy Alcohol Use Among Adults with HIV in Zambia: Results from a Pilot Randomized Controlled Trial.
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DOI：
10.1007/s10461-021-03408-4
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发表时间：
2022-03
影响因子：
4.4
通讯作者：
Vinikoor MJ
中科院分区：
文献类型：
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作者：
Kane JC;Sharma A;Murray LK;Chander G;Kanguya T;Skavenski S;Chitambi C;Lasater ME;Paul R;Cropsey K;Inoue S;Bosomprah S;Danielson CK;Chipungu J;Simenda F;Vinikoor MJ
这项随机对照试验测试了一种多疗程、循证、非专业咨询师提供的跨诊断疗法--共同要素治疗方法（CETA）在减少赞比亚艾滋病毒感染者（PLWH）不健康饮酒和合并症方面的疗效。成人PLWH（a）不健康的酒精使用加上精神健康或物质使用共病，或（B）严重不健康的酒精使用被随机接受单次酒精短暂干预（BI）单独或BI加转诊CETA。在基线和6个月随访时测量结果，包括酒精使用障碍识别测试（AUDIT）评分（主要），抑郁和创伤症状，以及其他物质使用（次要）。我们招募了160名参与者; 78名被随机分配到BI单药组，82名被随机分配到BI + CETA组。由于COVID-19，试验在36名参与者完成之前提前结束。从基线到6个月随访，两组的平均AUDIT评分均出现统计学和临床显著性降低，然而，与BI单药治疗相比，分配至BI + CETA组的受试者的降低幅度显著更大（− 3.2，95% CI − 6.2至− 0.1; Cohen d：0.48）。AUDIT评分的CETA效应量随着精神健康/物质使用合并症的增加而增加（0例合并症d = 0.25; 1-2例合并症d = 0.36; 3+合并症d = 1.6）。观察到CETA对抑郁症、创伤和其他几种物质的显著治疗效果。BI加CETA是可行的，并且在HIV感染者中，特别是在合并症患者中，对于不健康的酒精使用，优于单独使用BI的上级。研究结果支持未来的有效性测试CETA艾滋病毒的结果PLWH与不健康的酒精使用。临床试验编号：NCT 03966885
This randomized controlled trial tested the efficacy of a multi-session, evidence-based, lay counselor-delivered transdiagnostic therapy, the Common Elements Treatment Approach (CETA), in reducing unhealthy alcohol use and comorbidities among persons living with HIV (PLWH) in Zambia. Adult PLWH with (a) unhealthy alcohol use plus mental health or substance use comorbidities, or (b) severe unhealthy alcohol use were randomized to receive a single-session alcohol brief intervention (BI) alone or BI plus referral to CETA. Outcomes were measured at baseline and a 6-month follow-up and included Alcohol Use Disorders Identification Test (AUDIT) score (primary), depression and trauma symptoms, and other substance use (secondary). We enrolled 160 participants; 78 were randomized to BI alone and 82 to BI plus CETA. Due to COVID-19, the trial ended early before 36 participants completed. Statistically and clinically significant reductions in mean AUDIT score from baseline to 6-month follow-up were observed in both groups, however, participants assigned to BI plus CETA had significantly greater reductions compared to BI alone (− 3.2, 95% CI − 6.2 to − 0.1; Cohen’s d: 0.48). The CETA effect size for AUDIT score increased in line with increasing mental health/substance use comorbidity (0 comorbidities d = 0.25; 1–2 comorbidities d = 0.36; 3+ comorbidities d = 1.6). Significant CETA treatment effects were observed for depression, trauma, and several other substances. BI plus referral to CETA was feasible and superior to BI alone for unhealthy alcohol use among adults with HIV, particularly among those with comorbidities. Findings support future effectiveness testing of CETA for HIV outcomes among PLWH with unhealthy alcohol use. Clinical Trials Number: NCT03966885
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DOI：
10.1111/add.15112
发表时间：
2021-03
期刊：
Addiction (Abingdon, England)
影响因子：
--
作者：
Papas RK;Gakinya BN;Mwaniki MM;Lee H;Keter AK;Martino S;Klein DA;Liu T;Loxley MP;Sidle JE;Schlaudt K;Nafula T;Omodi VM;Baliddawa JB;Kinyanjui DW;Maisto SA
通讯作者：
Maisto SA
影响因子：
2.9
作者：
Rathod SD;Roberts T;Medhin G;Murhar V;Samudre S;Luitel NP;Selohilwe O;Ssebunnya J;Jordans MJD;Bhana A;Petersen I;Kigozi F;Nakku J;Lund C;Fekadu A;Shidhaye R
通讯作者：
Shidhaye R
影响因子：
3.8
作者：
Kalichman, Seth C.;Simbayi, Leickness C.;Jooste, Sean
通讯作者：
Jooste, Sean
影响因子：
3.9
作者：
Kane, J. C.;Van Wyk, S. Skavenski;Murray, L. K.
通讯作者：
Murray, L. K.
影响因子：
4.6
作者：
Hahn, Judith A;Samet, Jeffrey H
通讯作者：
Samet, Jeffrey H