Perfluorocarbon nanoemulsions for quantitative molecular imaging and targeted therapeutics.
Perfluorocarbon nanoemulsions for quantitative molecular imaging and targeted therapeutics.
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DOI：
10.1007/s10439-009-9643-z
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发表时间：
2009-10
影响因子：
3.8
通讯作者：
Wickline, Samuel A.
中科院分区：
文献类型：
--
作者：
Kaneda, Megan M.;Caruthers, Shelton;Lanza, Gregory M.;Wickline, Samuel A.
多种纳米材料可用作分子成像和药物输送的造影剂。由于体内缺乏内源性背景信号以及 19F 原子的高 NMR 灵敏度，液体全氟化碳纳米乳液成为细胞和磁共振分子成像的理想试剂。全氟化碳核心材料被脂质单层包围，该脂质单层可以用多种试剂功能化，包括单独或组合的靶向配体、显像剂和药物。多个拷贝的靶向配体（约 20-40 个单克隆抗体或 200-400 个小分子配体）可通过多价相互作用增强亲合力，而颗粒全氟化碳核心的成分会导致 19F 局部浓度较高。此外，分子靶向纳米乳剂中包含的亲脂性药物可以导致接触促进药物递送至靶细胞。最终，全氟化碳纳米粒子用于定点药物输送和分子成像的双重用途可以提供疾病状态的成像以及药物输送定位于感兴趣区域的确凿证据。本综述将重点关注液体全氟化碳纳米粒子作为 19F 分子成像剂以及用于癌症和心血管疾病的靶向药物输送。
A broad array of nanomaterials is available for use as contrast agents for molecular imaging and drug delivery. Due to the lack of endogenous background signal in vivo and the high NMR sensitivity of the 19F atom, liquid perfluorocarbon nanoemulsions make ideal agents for cellular and magnetic resonance molecular imaging. The perfluorocarbon core material is surrounded by a lipid monolayer which can be functionalized with a variety of agents including targeting ligands, imaging agents and drugs either individually or in combination. Multiple copies of targeting ligands (~20–40 monoclonal antibodies or 200–400 small molecule ligands) serve to enhance avidity through multivalent interactions while the composition of the particle’s perfluorocarbon core results in high local concentrations of 19F. Additionally, lipophilic drugs contained within molecularly targeted nanoemulsions can result in contact facilitated drug delivery to target cells. Ultimately, the dual use of perfluorocarbon nanoparticles for both site targeted drug delivery and molecular imaging may provide both imaging of disease states as well as conclusive evidence that drug delivery is localized to the area of interest. This review will focus on liquid perfluorocarbon nanoparticles as 19F molecular imaging agents and for targeted drug delivery in cancer and cardiovascular disease.
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DOI：
10.1164/ajrccm.165.6.2003052
发表时间：
2002-03-15
影响因子：
24.7
作者：
Hirschl, RB;Croce, M;Bartlett, RH
通讯作者：
Bartlett, RH
影响因子：
2.9
作者：
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Wickline, SA
影响因子：
4.3
作者：
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通讯作者：
Brindle, NPJ
影响因子：
37.8
作者：
Flacke, S;Fischer, S;Lanza, GM
通讯作者：
Lanza, GM
影响因子：
46.9
作者：
Ahrens, ET;Flores, R;Morel, PA
通讯作者：
Morel, PA