Virulence of Newcastle disease virus: what is known so far?

Virulence of Newcastle disease virus: what is known so far?
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DOI:
10.1186/1297-9716-42-122
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发表时间:
2011-12-23
影响因子:
4.4
通讯作者:
Peeters BP
Peeters BP
中科院分区:
农林科学2区
文献类型:
--
作者:
Dortmans JC;Koch G;Rottier PJ;Peeters BP

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在过去的十年中,人们对纽卡斯尔病毒(NDV)的毒力进行了大量的研究。这主要是由于反向遗传学系统的发展,使得对NDV进行遗传修饰并研究单个基因和基因组区域对其毒力的贡献成为可能。然而,现有的信息是分散的,缺乏对决定NDV毒力的因素和条件的全面概述。本文对NDV的毒力特性进行了总结、比较和讨论,指出NDV的毒力是一个由多种遗传因素决定的复杂性状。
In the last decade many studies have been performed on the virulence of Newcastle disease virus (NDV). This is mainly due to the development of reverse genetics systems which made it possible to genetically modify NDV and to investigate the contribution of individual genes and genome regions to its virulence. However, the available information is scattered and a comprehensive overview of the factors and conditions determining NDV virulence is lacking. This review summarises, compares and discusses the available literature and shows that virulence of NDV is a complex trait determined by multiple genetic factors.
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