Associations of blood and urinary mercury with hypertension in U.S. adults: the NHANES 2003-2006.
Associations of blood and urinary mercury with hypertension in U.S. adults: the NHANES 2003-2006.
复制标题
DOI：
10.1016/j.envres.2013.02.003
复制
发表时间：
2013-05
影响因子：
8.3
通讯作者：
Franzblau, Alfred
中科院分区：
文献类型：
--
作者：
Park, Sung Kyun;Lee, Sunghee;Basu, Niladri;Franzblau, Alfred
很少有研究调查普通人群中高血压与汞接触之间的关系。我们研究了具有代表性的美国成年人血液（主要是甲基汞）或尿汞（主要是无机汞）与高血压之间的横断面关系，以及饮食中omega-3脂肪酸和血清硒的影响。我们使用2003/2004年至2005/2006年的国家健康和营养检查调查（NHANES），对6607名20岁或以上的成年人进行了检查（2201名可从NHANES 2003-2006年获得尿汞；2117名可从NHANES 2003-2004年获得血清硒，年龄在40岁或以上）。计算了两次24小时召回中omega-3脂肪酸的平均值。高血压加权患病率为32.2%。血总汞和尿汞的几何均值（95%可信区间）分别为1.03（0.95、1.11）µg/L和0.51（0.47、0.54）µg/L。校正潜在混杂因素后，血汞和尿汞增加一倍的校正优势比分别为0.94（0.87至1.01）和0.87（0.78至0.99）。即使在调整了omega-3脂肪酸或硒或两者后，这种关联仍然相似。omega-3脂肪酸或硒均未观察到明显的效果改变。在这项针对美国普通人群的横断面研究中，我们发现高血压与血汞没有关联，但与尿汞呈负相关。未来的前瞻性研究有必要证实这些发现。
Few studies have examined the association between hypertension and mercury exposure in the general population. We examined cross-sectional associations between blood (mainly methylmercury) or urinary mercury (mainly inorganic mercury) and hypertension in representative U.S. adults and effect modifications by dietary omega-3 fatty acids and serum selenium. We examined 6,607 adults aged 20 years or older, using the National Health and Nutrition Examination Survey (NHANES) from 2003/2004 to 2005/2006 (2,201 adults were available for urinary mercury from NHANES 2003–2006; 2,117 available for serum selenium from NHANES 2003–2004 aged 40 years or older). The average of omega-3 fatty acids from two 24-hour recalls was calculated. The weighted prevalence of hypertension was 32.2%. The geometric means (95% confidence intervals) of blood total and urinary mercury were 1.03 (0.95, 1.11) µg/L and 0.51 (0.47, 0.54) µg/L, respectively. The adjusted odds ratios for a doubling increase in blood mercury and urinary mercury were 0.94 (0.87 to 1.01) and 0.87 (0.78 to 0.99), respectively, after adjusting for potential confounders. The associations remained similar, even after adjusting for either omega-3 fatty acids or selenium or both. No significant effect modification by either omega-3 fatty acids or selenium was observed. In this cross-sectional study of the U.S. general population, we found no association of hypertension with blood mercury but a suggestive inverse association with urinary mercury. Future prospective studies are warranted to confirm these findings.
登录
查看更多内容
影响因子：
8.3
作者：
Fields, LE;Burt, VL;Sorlie, P
通讯作者：
Sorlie, P
影响因子：
7.7
作者：
Cole, Stephen R.;Chu, Haitao;Schisterman, Enrique F.
通讯作者：
Schisterman, Enrique F.
DOI：
10.1186/1476-069x-5-29
发表时间：
2006-10-10
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Fillion, Myriam;Mergler, Donna;Guimaraes, Jean Remy Davee
通讯作者：
Guimaraes, Jean Remy Davee
影响因子：
6.1
作者：
GUO, TZ;BAASNER, J
通讯作者：
BAASNER, J
影响因子：
7.2
作者：
Ostchega, Y;Prineas, RJ;Collins, D
通讯作者：
Collins, D