GnRH pulsatility, the pituitary response and reproductive dysfunction.
GnRH pulsatility, the pituitary response and reproductive dysfunction.
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DOI：
10.1507/endocrj.k09e-185
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发表时间：
2009
影响因子：
2
通讯作者：
Webster NJ
中科院分区：
文献类型：
--
作者：
Tsutsumi R;Webster NJ
GnRH在生殖功能的神经内分泌控制中起重要作用。在哺乳动物中，促性腺激素分泌的模式包括脉冲和浪涌阶段，这是独立调节的。GnRH和LH的脉冲式释放在性功能的发育和月经周期的正常调节中起着重要作用。一系列经典研究证实了GnRH脉动的重要性。当GnRH脉动受到慢性营养不良、热量消耗过多或衰老的抑制时，生育力就会受损。许多女性生殖系统疾病，包括低促性腺激素性性腺功能减退症、低淋巴细胞性闭经、高泌乳素血症和多囊卵巢综合征（PCOS），也与正常脉冲式GnRH分泌中断有关。尽管有这些发现，但这种脉动式GnRH调节的分子机制还不清楚。在这里，我们回顾了最近的研究GnRH脉动，信号和转录反应，及其对疾病的影响。
GnRH plays an essential role in neuroendocrine control of reproductive function. In mammals, the pattern of gonadotropin secretion includes both pulse and surge phases, which are regulated independently. The pulsatile release of GnRH and LH plays an important role in the development of sexual function and in the normal regulation of the menstrual cycle. The importance of GnRH pulsatility was established in a series of classic studies. Fertility is impaired when GnRH pulsatility is inhibited by chronic malnutrition, excessive caloric expenditure, or aging. A number of reproductive disorders in women with including hypogonadotropic hypogonadism, hypothlamic amenorrhea, hyperprolactinemia and polycystic ovary syndrome (PCOS) are also associated with disruption of the normal pulsatile GnRH secretion. Despite these findings, the molecular mechanisms of this pulsatile GnRH regulation are not well understood. Here, we review recent studies about GnRH pulsatility, signaling and transcriptional response, and its implications for disease.
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