Recombination and the progression of meiosis in Saccharomyces cerevisiae.

Recombination and the progression of meiosis in Saccharomyces cerevisiae.
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酿酒酵母的重组和减数分裂的进展。

DOI:
10.1093/genetics/146.2.481
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发表时间:
1997
期刊:
影响因子:
3.3
通讯作者:
Malone,RE
Malone,RE
中科院分区:
生物学2区
文献类型:
--
作者:
Galbraith,AM;Bullard,SA;Jiao,K;Nau,JJ;Malone,RE

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重组是减数分裂的重要组成部分;在几乎所有的生物中,包括酿酒酵母在内,适当的染色体分离和减数分裂产物的活性取决于正常的重组水平。在这篇文章中,我们研究了四个在启动重组过程中有缺陷的突变体的减数分裂动力学。我们发现,三个早期Exchange基因(REC104、REC114或REC102)中的任何一个突变都赋予了一种表型,在这种表型中,还原分裂发生得比同基因野生型二倍体更早。我们还提供了一些数据,证实了之前的报道,即早期Exchange基因MEI4突变的菌株与野生型细胞几乎同时进行第一次分裂。104号突变对ME4号突变的第一次分裂时间具有上位性。这些观察结果表明,重组的启动和还原分裂的时机之间可能存在关系。这些数据还可以根据它们在协调重组和还原分裂方面的作用来区分这四个被检测的早期交换基因。
Recombination is an essential part of meiosis; in almost all organisms, includingSaccharomyces cerevisiae,proper chromosome segregation and the viability of meiotic products is dependent upon normal levels of recombination. In this article we examine the kinetics of the meiotic divisions in four mutants defective in the initiation of recombination. We find that mutations in any of three Early Exchange genes (REC104, REC114orREC102) confer a phenotype in which the reductional division occurs earlier than in an isogenic wild-type diploid. We also present data confirming previous reports that strains with a mutation in the Early Exchange geneMEI4undergo the first division at about the same time as wild-type cells. Therec104mutation is epistatic to themei4mutation for the timing of the first division. These observations suggest a possible relationship between the initiation of recombination and the timing of the reductional division. These data also allow these four Early Exchange genes examined to be distinguished in terms of their role in coordinating recombination with the reductional division.
DOI: 10.1093/genetics/144.1.71
发表时间: 1996
期刊: Genetics
影响因子: 3.3
作者:
Mao-Draayer,Y;Galbraith,AM;Pittman,DL;Cool,M;Malone,RE
通讯作者: Malone,RE
酵母减数分裂突变体中异源双链 DNA 的形成和同源配对。
DOI: 10.1093/genetics/141.1.75
发表时间: 1995
期刊: Genetics
影响因子: 3.3
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酿酒酵母中起始突变的粗线期停滞和其他减数分裂效应。
DOI: --
发表时间: 1989
期刊: Genetics
影响因子: 3.3
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RAD9 依赖性检查点可阻断 cdc13 酵母细胞的减数分裂。
DOI: 10.1093/genetics/131.1.55
发表时间: 1992
期刊: Genetics
影响因子: 3.3
作者:
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通讯作者: Byers,B
DOI: --
发表时间: 1985-06
期刊: Genetics
影响因子: 3.3
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