On the temporal relationship between throbbing migraine pain and arterial pulse.
On the temporal relationship between throbbing migraine pain and arterial pulse.
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DOI：
10.1111/j.1526-4610.2010.01765.x
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发表时间：
2010-10
期刊：
影响因子：
5
通讯作者：
Ahn AH
中科院分区：
文献类型：
--
作者：
Ahn AH
偏头痛的特征性搏动质量通常归因于在心脏收缩期间由颅动脉扩张触发的三叉神经血管感觉传入神经的周期性激活，但该模型的直接证据一直难以捉摸。搏动性偏头痛患者被要求在真实的时间内发出信号，告知他们主观感受到的搏动性疼痛的发生，在此期间，他们的动脉脉搏被独立监测。总体而言，搏动性疼痛率（61.7 ± 5.5 SEM）显著低于动脉搏动率（80 ± 2.6 SEM，p <0.02），在少数两种速率相同或几乎相同的个体中，搏动和动脉搏动的发生彼此同相或异相。搏动性疼痛的主观体验与动脉脉搏之间缺乏简单的对应关系，至少需要对流行的观点进行广泛的改进，即搏动性偏头痛的主观体验与颅动脉的扩张和相关感觉传入的激活直接相关。
The characteristic throbbing quality of migraine pain is often attributed to the periodic activation of trigeminovascular sensory afferents triggered by the distension of cranial arteries during systole, but direct evidence for this model has been elusive. Patients with throbbing migrainous pain were asked to signal in real time the occurrences of their subjective experience of pulsating pain, during which time their arterial pulse was independently monitored. Overall, the throbbing pain rate (61.7 ± 5.5 SEM) was substantially slower than the arterial pulse rate (80 ± 2.6 SEM, p < .02), and among the few individuals in whom the two rates were the same or nearly the same, the occurrences of throbbing and arterial pulsations fell in and out of phase with each other. The lack of a simple correspondence between the subjective experience of throbbing pain and the arterial pulse would at the very least require extensive refinement of the prevailing view that the subjective experience of throbbing migraine pain is directly related to the distension of cranial arteries and activation of associated sensory afferents.
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