The Role of Regulatory T Cells in Epicutaneous Immunotherapy for Food Allergy.
The Role of Regulatory T Cells in Epicutaneous Immunotherapy for Food Allergy.
复制标题
调节性 T 细胞在食物过敏皮下免疫治疗中的作用
DOI：
10.3389/fimmu.2021.660974
复制
发表时间：
2021
影响因子：
7.3
通讯作者：
Che H
中科院分区：
文献类型：
--
作者：
Liu G;Liu M;Wang J;Mou Y;Che H
近几十年来，食物过敏的流行迅速增加，导致了对新的治疗策略及其机制的广泛研究。小鼠模型已经为皮肤免疫疗法(EPIT)诱导免疫耐受的机制提供了初步的见解。在EPIT中，施加在皮肤表面的抗原可以被抗原提呈细胞(APC)捕获、处理并呈递到淋巴结(LNS)。在LNS中，调节性T细胞(Treg细胞)的诱导既需要抗原呈递过程中的直接接触，也需要间接机制，如细胞因子。Foxp3+CD62L+Treg细胞可以表现出Foxp3 TSDR和Foxp3-LAP+Treg细胞的低甲基化特征，从而增加表面组织特异性归巢分子的表达，从而进一步发挥持续的全身免疫耐受。研究表明，EPIT是一种潜在的治疗食物过敏的药物，并能有效地诱导免疫耐受，但其机制尚需进一步探讨。本文综述了Treg细胞在EPIT诱导免疫耐受中的作用，为进一步研究EPIT的作用机制和开发更有效的EPIT治疗方法提供了理论基础。
In recent decades, a rapid increase in the prevalence of food allergies has led to extensive research on novel treatment strategies and their mechanisms. Mouse models have provided preliminary insights into the mechanism of epicutaneous immunotherapy (EPIT)-induced immune tolerance. In EPIT, antigen applied on the skin surface can be captured, processed, and presented in the lymph nodes (LNs) by Antigen-presenting cells (APCs). In the LNs, induction of regulatory T cells (Treg cells) requires both direct contact during antigen presentation and indirect mechanisms such as cytokines. Foxp3+CD62L+ Treg cells can exhibit the characteristics of hypomethylation of Foxp3 TSDR and Foxp3-LAP+ Treg cells, which increase the expression of surface tissue-specific homing molecules to exert further sustained systemic immune tolerance. Studies have shown that EPIT is a potential treatment for food allergies and can effectively induce immune tolerance, but its mechanism needs further exploration. Here, we review Treg cells’ role in immune tolerance induced by EPIT and provide a theoretical basis for future research directions, such as the mechanism of EPIT and the development of more effective EPIT treatments.
登录
查看更多内容
DOI：
10.1073/pnas.79.22.6861
发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
BRESLOW, JL;ROSS, D;ZANNIS, VI
通讯作者：
ZANNIS, VI
具有 I-J 决定簇的抑制性 T 细胞的特异性富集：平行功能和血清学特征。
影响因子：
15.3
作者：
Okumura, K;Takemori, T;Tokuhisa, T;Tada, T
通讯作者：
Tada, T
DOI：
10.1111/cea.12312
发表时间：
2014-06
期刊：
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
影响因子：
--
作者：
Dioszeghy V;Mondoulet L;Dhelft V;Ligouis M;Puteaux E;Dupont C;Benhamou PH
通讯作者：
Benhamou PH
影响因子：
14.2
作者：
Buchanan, Ariana D.;Green, Todd D.;Burks, A. Wesley
通讯作者：
Burks, A. Wesley
影响因子：
4.4
作者：
Dioszeghy, Vincent;Mondoulet, Lucie;Dupont, Christophe
通讯作者：
Dupont, Christophe