Early partial systolic closure of the pulmonic valve relates to severity of pulmonary hypertension.
Early partial systolic closure of the pulmonic valve relates to severity of pulmonary hypertension.
复制标题
肺动脉瓣早期部分收缩期关闭与肺动脉高压的严重程度有关。
DOI：
10.1016/0002-8703(88)90489-9
复制
发表时间：
1988
影响因子：
4.8
通讯作者：
Reeves,JT
中科院分区：
文献类型：
--
作者：
Turkevich,D;Groves,BM;Micco,A;Trapp,JA;Reeves,JT
肺动脉高压的超声检查通常显示肺动脉瓣收缩期部分关闭和多普勒肺血流速度的早期峰值，但这些发现尚不清楚。我们对早期收缩期部分关闭伴高肺动脉压的初步观察表明，这种现象可能与压力有关。在30例有记录的肺动脉高压患者中，收缩期部分关闭的时间和相应的多普勒血流速度的下降与置管时肺动脉压呈负相关。峰值流量先于收缩速度下降，且与压力成反比。由于血流速度的变化可能反映了通过瓣膜的驱动力的变化，我们检查了24例有或无肺动脉高压的患者右心室和肺动脉同时进行的高保真导管压力追踪。在30项研究中，收缩期早期右室-肺动脉压力梯度呈阳性，但在收缩期中后期梯度降至最小值。这个最小值的时间也与压力成反比。我们推测肺动脉高压中反射血的力量发生得更早，从而减少了向前的驱动力，使部分收缩期提前关闭。
Ultrasound studies in pulmonary hypertension often show systolic partial closure of the pulmonic valve and early peaking of Doppler pulmonary flow velocity, but these findings are poorly understood. Our initial observations of earlier systolic partial closure with higher pulmonary pressures suggested that this phenomenon might relate to pressure. In 30 patients with documented pulmonary hypertension, the timing of systolic partial closure and the corresponding decrease in Doppler flow velocity related inversely to pulmonary artery pressure at catheterization. Peak flow precedec the systolic velocity decrease and also related inversely to pressure. Since changing flow velocity might reflect a changing driving force across the valve, we examined simultaneous high-fidelity catheter pressure tracings from the right ventricle and pulmonary artery from 24 patients with and without pulmonary hypertension. In 30 studies, a positive right ventricular to pulmonary artery pressure gradient was present early in systole, but the gradient decreased to a minimum value in mid-to-late systole. The timing of this minimum also related inversely to pressure. We conjectured that forces opposing ejection occur earlier in pulmonary hypertension, thereby decreasing the forward driving force and allowing earlier partial systolic closure.
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影响因子：
20.1
作者：
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影响因子：
20.1
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影响因子：
4.8
作者：
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影响因子：
20.1
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