The DARK Side of Total Synthesis: Strategies and Tactics in Psychoactive Drug Production.
The DARK Side of Total Synthesis: Strategies and Tactics in Psychoactive Drug Production.
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DOI：
10.1021/acschemneuro.7b00528
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发表时间：
2018-10-17
影响因子：
5
通讯作者：
Townsend SD
中科院分区：
文献类型：
--
作者：
Chambers SA;DeSousa JM;Huseman ED;Townsend SD
Humankind has used and abused psychoactive drugs for millennia. Formally, a psychoactive drug is any agent that alters cognition and mood. The term “psychotropic drug” is neutral and describes the entire class of substrates, licit and illicit, of interest to governmental drug policy. While these drugs are prescribed for issues ranging from pain management to anxiety, they are also used recreationally. In fact, the current opioid epidemic is the deadliest drug crisis in American history. While the topic is highly politicized with racial, gender, and socioeconomic elements, there is no denying the toll drug mis- and overuse is taking on this country. Overdose, fueled by opioids, is the leading cause of death for Americans under 50 years of age, killing ca. 64,000 people in 2016. From a chemistry standpoint, the question is in what ways, if any, did organic chemists contribute to this problem? In this targeted review, we provide brief historical accounts of the main classes of psychoactive drugs and discuss several foundational total syntheses that ultimately provide the groundwork for producing these molecules in academic, industrial, and clandestine settings.
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DOI：
10.1039/jr9560004589
发表时间：
1956-01-01
期刊：
JOURNAL OF THE CHEMICAL SOCIETY
影响因子：
--
作者：
ABRAMOVITCH, RA;SHAPIRO, D
通讯作者：
SHAPIRO, D
影响因子：
3.6
作者：
GATES, M
通讯作者：
GATES, M
影响因子：
15
作者：
GATES, M
通讯作者：
GATES, M
影响因子：
5.4
作者：
Endoma-Arias, Mary Ann A.;Cox, D. Phillip;Hudlicky, Tomas
通讯作者：
Hudlicky, Tomas
影响因子：
2.9
作者：
Brandt, Simon D.;Moore, Sharon A.;Kanu, Abu B.
通讯作者：
Kanu, Abu B.