Effects of cardiac rehabilitation with and without meditation on myocardial blood flow using quantitative positron emission tomography: A pilot study.
Effects of cardiac rehabilitation with and without meditation on myocardial blood flow using quantitative positron emission tomography: A pilot study.
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DOI：
10.1007/s12350-019-01884-9
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发表时间：
2021-08
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--
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社会心理压力被认为是冠心病（CHD）的危险因素。非裔美国人的高冠心病发病率可能与心理社会压力有关。然而，标准的心脏康复（CR）通常不包括系统的减压技术。以往的研究表明，超越冥想（TM）技术可以减少冠心病的危险因素和临床事件。本初步研究探讨了标准CR伴和不伴TM对非裔美国患者冠心病的影响。56例冠心病患者被分配到CR、CR+TM、单独TM或常规护理组。测试分别在基线和12周后进行。主要终点是心肌血流储备（MFR），通过13n -氨正电子发射断层扫描（PET）评估。次要结局为冠心病危险因素。根据小型试点研究分析指南，对数据进行效应量（ES）分析。在完成后测的37例患者中，CR+TM组（+20.7%，ES= 0.64）和单独TM组（+12.8%，ES= 0.36）的MFR改善。相比之下，单独的CR组和常规护理组分别显示了适度的变化（+5.8%，ES= 0.17和- 10.3%，ES= - 0.31）。联合TM组的MFR较联合No组（- 2.0%，ES= - 0.08）增加（+14%，ES= 0.56）。这些试点数据表明，将TM技术加入标准心脏康复或单独使用TM可改善非裔美国冠心病患者的心肌血流储备。这些结果可以应用于对照临床试验的设计，以明确地测试这些效果。
Psychosocial stress is recognized as a risk factor for coronary heart disease (CHD). High rates of CHD in African Americans may be related to psychosocial stress. However, standard cardiac rehabilitation (CR) usually does not include a systematic stress reduction technique. Previous studies suggest that the Transcendental Meditation (TM) technique may reduce CHD risk factors and clinical events. This pilot study explored the effects of standard CR with and without TM on a measure of CHD in African American patients. Fifty-six CHD patients were assigned to either CR, CR+TM, TM alone, or usual care. Testing was done at baseline and after 12 weeks. The primary outcome was myocardial flow reserve (MFR) assessed by 13N-ammonia positron emission tomography (PET). Secondary outcomes were CHD risk factors. Based on guidelines for analysis of small pilot studies, data was analyzed for effect size (ES). For 37 patients who completed posttesting, there were MFR improvements in the CR+TM group (+20.7%; ES= 0.64) and the TM group alone (+12.8%; ES= 0.36). By comparison, the CR alone and usual care groups showed modest changes (+5.8%; ES= 0.17 and −10.3%; ES= −0.31) respectively. For the combined TM group, MFR increased (+14%, ES= .56) compared to the combined No TM group (−2.0%, ES=−.08). These pilot data suggest that adding the TM technique to standard cardiac rehabilitation or using TM alone may improve myocardial flow reserve in African American CHD patients. These results may be applied to the design of controlled clinical trials to definitively test these effects.
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影响因子：
37.8
作者：
Gupta A;Taqueti VR;van de Hoef TP;Bajaj NS;Bravo PE;Murthy VL;Osborne MT;Seidelmann SB;Vita T;Bibbo CF;Harrington M;Hainer J;Rimoldi O;Dorbala S;Bhatt DL;Blankstein R;Camici PG;Di Carli MF
通讯作者：
Di Carli MF
影响因子：
37.8
作者：
Blumenthal JA;Sherwood A;Smith PJ;Watkins L;Mabe S;Kraus WE;Ingle K;Miller P;Hinderliter A
通讯作者：
Hinderliter A
影响因子：
37.8
作者：
Balady, Gary J.;Williams, Mark A.;Southard, Douglas
通讯作者：
Southard, Douglas
影响因子：
37.8
作者：
Klocke, FJ;Baird, MG;Russell, RO
通讯作者：
Russell, RO
影响因子：
2.7
作者：
Orme-Johnson, DW;Walton, KG
通讯作者：
Walton, KG