ErbB4 acts as a suppressor in colitis and its associated carcinoma by negatively regulating cholesterol metabolism.
ErbB4 acts as a suppressor in colitis and its associated carcinoma by negatively regulating cholesterol metabolism.
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ErbB4 通过负向调节胆固醇代谢，充当结肠炎及其相关癌症的抑制剂。
DOI：
10.1093/carcin/bgy164
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发表时间：
2018-11
期刊：
影响因子：
4.7
通讯作者：
Li Jianming
中科院分区：
文献类型：
--
作者：
Ni Hengli;Chen Lin;Song Liming;Sun Lina;Cui Hongxia;Zhou Qun;Hu Caihong;Jiao Weijuan;Shen Tong;Gao Tianming;Liu Yao;Li Jianming
Previously we reported that ErbB4 played a protective role in chronic liver injury and hepatocellular carcinoma. Herein, we examined the role of ErbB4 in the development of colitis-associated cancer (CAC) in ErbB4 knockout mice models, in vitro cell lines and clinical samples. We found that ErbB4 deficiency may lead to more severe inflammation, slower recovery, and the development of CAC. Further, loss of ErbB4 could activate KRAS by up regulating rate-limiting enzymes in cholesterol metabolism pathway through interacting with the transcription factor SREBF1. In clinic samples, ErbB4 is down-regulated in colonic tissues from Crohn's disease patients. And data from The Cancer Genome Atlas also showed significant negative correlation between ErbB4 and several cholesterol metabolic enzymes. In conclusion, our study uncovers ErbB4 as a protector in the development of colitis-associated cancer, for its loss could activate KRAS by up regulating cholesterol metabolism through interaction with SREBF1.
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影响因子：
11.2
作者：
Fuentes NR;Mlih M;Barhoumi R;Fan YY;Hardin P;Steele TJ;Behmer S;Prior IA;Karpac J;Chapkin RS
通讯作者：
Chapkin RS
DOI：
10.1152/ajplung.00131.2010
发表时间：
2011-10-01
影响因子：
4.9
作者：
Schmiedl, Andreas;Behrens, Jan;Dammann, Christiane E. L.
通讯作者：
Dammann, Christiane E. L.
影响因子：
78.5
作者：
N. Hynes;H. Lane
通讯作者：
N. Hynes;H. Lane
DOI：
10.1073/pnas.1436402100
发表时间：
2003-07-08
影响因子：
11.1
作者：
Tidcombe, H;Jackson-Fisher, A;Golding, JP
通讯作者：
Golding, JP
影响因子：
6
作者：
McElroy, Steven J.;Castle, Shannon L.;Frey, Mark R.
通讯作者：
Frey, Mark R.