Stem cell-based therapies for atherosclerosis: perspectives and ongoing controversies.
Stem cell-based therapies for atherosclerosis: perspectives and ongoing controversies.
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基于干细胞的动脉粥样硬化疗法：前景和持续的争议。
DOI：
10.1089/scd.2014.0078
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发表时间：
2014-04
影响因子：
4
通讯作者：
Wang, Jian-An
中科院分区：
文献类型：
--
作者：
Chen, Huiqiang;Chen, Han;Yu, Hong;Wang, Jian-An
动脉粥样硬化是危及生命的心血管事件的主要原因，是全球死亡的主要原因。由于动脉粥样硬化的发病机制尚未完全清楚，目前还没有有效的方法来逆转动脉粥样硬化。因此，迫切需要探索预防或逆转动脉粥样硬化进展的机制和潜在的治疗策略。近年来，基于干细胞的疗法已经有望治疗各种疾病，包括动脉粥样硬化。不幸的是，文献中报道的基于干细胞的治疗动脉粥样硬化的疗效不一致，甚至相互矛盾。本文综述了近年来干细胞治疗动脉粥样硬化的研究进展，并探讨了干细胞治疗动脉粥样硬化的可能机制和未来发展方向。
Atherosclerosis is a major contributor to life-threatening cardiovascular events, the leading cause of death worldwide. Since the mechanisms of atherosclerosis have not been fully understood, currently, there are no effective approaches to regressing atherosclerosis. Therefore, there is a dire need to explore the mechanisms and potential therapeutic strategies to prevent or reverse the progression of atherosclerosis. In recent years, stem cell-based therapies have held promises to various diseases, including atherosclerosis. Unfortunately, the efficacy of stem cell-based therapies for atherosclerosis as reported in the literature has been inconsistent or even conflicting. In this review, we summarize the current literature of stem cell-based therapies for atherosclerosis and discuss possible mechanisms and future directions of these potential therapies.
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影响因子：
20.3
作者：
Sato, Kazuya;Ozaki, Katsutoshi;Ozawa, Keiya
通讯作者：
Ozawa, Keiya
影响因子：
37.8
作者：
Go AS;Mozaffarian D;Roger VL;Benjamin EJ;Berry JD;Blaha MJ;Dai S;Ford ES;Fox CS;Franco S;Fullerton HJ;Gillespie C;Hailpern SM;Heit JA;Howard VJ;Huffman MD;Judd SE;Kissela BM;Kittner SJ;Lackland DT;Lichtman JH;Lisabeth LD;Mackey RH;Magid DJ;Marcus GM;Marelli A;Matchar DB;McGuire DK;Mohler ER 3rd;Moy CS;Mussolino ME;Neumar RW;Nichol G;Pandey DK;Paynter NP;Reeves MJ;Sorlie PD;Stein J;Towfighi A;Turan TN;Virani SS;Wong ND;Woo D;Turner MB;American Heart Association Statistics Committee and Stroke Statistics Subcommittee
通讯作者：
American Heart Association Statistics Committee and Stroke Statistics Subcommittee
影响因子：
56.9
作者：
Asahara, T;Murohara, T;Isner, JM
通讯作者：
Isner, JM
DOI：
10.1161/01.atv.0000247243.48542.9d
发表时间：
2006-12-01
影响因子：
8.7
作者：
Bentzon, Jacob F.;Weile, Charlotte;Falk, Erling
通讯作者：
Falk, Erling
DOI：
10.1073/pnas.78.12.7545
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
BASU, SK;BROWN, MS;GOLDSTEIN, JL
通讯作者：
GOLDSTEIN, JL