Flos puerariae ameliorates the intestinal inflammation of Drosophila via modulating the Nrf2/Keap1, JAK-STAT and Wnt signaling.
Flos puerariae ameliorates the intestinal inflammation of Drosophila via modulating the Nrf2/Keap1, JAK-STAT and Wnt signaling.
复制标题
Flos puerariae通过调节NRF2/KEAP1，JAK-STAT和WNT信号传导来改善果蝇的肠炎。
DOI：
10.3389/fphar.2022.893758
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发表时间：
2022
影响因子：
5.6
通讯作者：
He, Jianzheng
中科院分区：
文献类型：
--
作者：
Yang, Shipei;Li, Xu;Xiu, Minghui;Dai, Yuting;Wan, Shengfang;Shi, Yan;Liu, Yongqi;He, Jianzheng
关键词：
Gut homeostasis is important for human health, and its disruption can lead to inflammatory bowel disease (IBD). Flos Puerariae is a herb with a wide variety of pharmacological activities including antioxidant, antidiabetic, antialcoholismic and anti-inflammatory properties. However, the role of Flos Puerariae on treating IBD remains obscure. Here, we employed Drosophila melanogaster as a model organism to investigate the protective effect of Flos Puerariae extract (FPE) against sodium dodecyl sulfate (SDS)-induced intestinal injury. Our data showed that FPE had no toxic effect in flies, and significantly extended lifespan in SDS-inflamed flies, reduced stem cell proliferation in the midgut, and maintained intestinal morphological integrity. Furthermore, FPE remarkably recused the altered expression level of genes and proteins in Nrf2/Keap1 signaling, JAK-STAT signaling and Wnt signaling pathways in gut of inflammation flies. Thus, FPE has a protective effect against intestinal injury possibly via increasing the Nrf2/keap1 pathway and suppressing the JAK-STAT and Wnt signaling pathways, which would have tremendous potential for treating IBD.
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影响因子：
29.4
作者：
Abraham C;Dulai PS;Vermeire S;Sandborn WJ
通讯作者：
Sandborn WJ
影响因子：
4.5
作者：
Chakrabarti S;Dudzic JP;Li X;Collas EJ;Boquete JP;Lemaitre B
通讯作者：
Lemaitre B
影响因子：
4
作者：
He J;Li B;Han S;Zhang Y;Liu K;Yi S;Liu Y;Xiu M
通讯作者：
Xiu M
影响因子：
4.6
作者：
Hämäläinen M;Nieminen R;Vuorela P;Heinonen M;Moilanen E
通讯作者：
Moilanen E
影响因子：
1.2
作者：
Bach, Erika A.;Ekas, Laura A.;Baeg, Gyeong-Hun
通讯作者：
Baeg, Gyeong-Hun