Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages.
Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages.
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DOI：
10.1155/2007/45673
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发表时间：
2007
影响因子：
4.6
通讯作者：
Moilanen E
中科院分区：
文献类型：
--
作者：
Hämäläinen M;Nieminen R;Vuorela P;Heinonen M;Moilanen E
在炎症中，细菌产物和促炎细胞因子通过诱导型一氧化氮合酶（iNOS）诱导大量一氧化氮（NO）的形成，抑制NO产生的化合物具有抗炎作用。在本研究中，我们系统地研究了 36 种天然存在的黄酮类化合物和相关化合物对暴露于炎症刺激物（脂多糖，LPS）的巨噬细胞中 NO 产生的影响，并评估了有效化合物的作用机制。黄酮、异黄酮黄豆苷元和金雀异黄酮、黄酮醇异鼠李素、山奈酚和槲皮素、黄烷酮柚皮素和花青素天竺葵素以剂量依赖性方式抑制 iNOS 蛋白和 mRNA 表达以及 NO 产生。所有八种活性化合物均抑制核因子 B (NF-B) 的激活，核因子 B 是 iNOS 的重要转录因子。金雀异黄素、山奈酚、槲皮素和大豆苷元还抑制信号转导子和转录激活子 1 (STAT-1)（iNOS 的另一个重要转录因子）的激活。本研究描述了天然存在的酚类化合物对活化巨噬细胞中 iNOS 表达和 NO 产生的影响和机制。结果部分解释了类黄酮作为抗炎化合物的药理学功效。
In inflammation, bacterial products and proinflammatory cytokines induce the formation of large amounts of nitric oxide (NO) by inducible nitric oxide synthase (iNOS), and compounds that inhibit NO production have anti-inflammatory effects. In the present study, we systematically investigated the effects of 36 naturally occurring flavonoids and related compounds on NO production in macrophages exposed to an inflammatory stimulus (lipopolysaccharide, LPS), and evaluated the mechanisms of action of the effective compounds. Flavone, the isoflavones daidzein and genistein, the flavonols isorhamnetin, kaempferol and quercetin, the flavanone naringenin, and the anthocyanin pelargonidin inhibited iNOS protein and mRNA expression and also NO production in a dose-dependent manner. All eight active compounds inhibited the activation of nuclear factor-B (NF-B), which is a significant transcription factor for iNOS. Genistein, kaempferol, quercetin, and daidzein also inhibited the activation of the signal transducer and activator of transcription 1 (STAT-1), another important transcription factor for iNOS. The present study characterises the effects and mechanisms of naturally occurring phenolic compounds on iNOS expression and NO production in activated macrophages. The results partially explain the pharmacological efficacy of flavonoids as anti-inflammatory compounds.
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影响因子：
5.6
作者：
Lin, HY;Shen, SC;Chen, YC
通讯作者：
Chen, YC
影响因子：
2.9
作者：
GREEN, LC;WAGNER, DA;TANNENBAUM, SR
通讯作者：
TANNENBAUM, SR
影响因子：
5.8
作者：
Mamani-Matsuda, Maria;Kauss, Tina;Mossalayi, M. Djavad
通讯作者：
Mossalayi, M. Djavad
影响因子：
7.3
作者：
Ruetten, H;Thiemermann, C
通讯作者：
Thiemermann, C
影响因子：
6.1
作者：
Autore, G;Rastrelli, L;Aquino, R
通讯作者：
Aquino, R