PDGF Family Expression in Glioblastoma Multiforme: Data Compilation from Ivy Glioblastoma Atlas Project Database.
PDGF Family Expression in Glioblastoma Multiforme: Data Compilation from Ivy Glioblastoma Atlas Project Database.
复制标题
DOI：
10.1038/s41598-017-15045-w
复制
发表时间：
2017-11-10
影响因子：
4.6
通讯作者：
de Oliveira JRM
中科院分区：
文献类型：
--
作者：
Cantanhede IG;de Oliveira JRM
多形性胶质母细胞瘤（GBM）是最常见和致命的原发性脑癌。由于其治疗抗性和侵袭性，其临床管理具有挑战性。血小板源性生长因子（PDGF）基因已被招募为这种肿瘤进展的驱动因素以及潜在的治疗靶点。由于文献中缺乏对PDGF系统在GBM瘤内和瘤间异质性背景下的表达模式的详细了解，本研究旨在表征不同组织学定义的GBM区域中的PDGF表达，以及研究这些基因表达与不良预后相关参数的相关性。来自36个GBM的多个切片的PDGF亚基的Z-评分标准化表达值，以及关于那些GBM患者的临床和基因组数据，由Ivy胶质母细胞瘤Atlas项目-艾伦脑科学研究所数据集汇编。PDGF亚基在GBM的不同区域显示差异表达，并且PDGF家族在受GBM影响的不同脑叶中不均一地表达。此外，PDGF家族表达与不良预后因素相关：GBM诊断时的年龄，磷酸酶和张力蛋白同源物缺失和异柠檬酸脱氢酶1突变。这些发现可能有助于GBM的临床管理和针对这种毁灭性肿瘤的靶向治疗疗法的发展。
Glioblastoma Multiforme (GBM) is the most frequent and lethal primary brain cancer. Due to its therapeutic resistance and aggressiveness, its clinical management is challenging. Platelet-derived Growth Factor (PDGF) genes have been enrolled as drivers of this tumour progression as well as potential therapeutic targets. As detailed understanding of the expression pattern of PDGF system in the context of GBM intra- and intertumoral heterogeneity is lacking in the literature, this study aims at characterising PDGF expression in different histologically-defined GBM regions as well as investigating correlation of these genes expression with parameters related to poor prognosis. Z-score normalised expression values of PDGF subunits from multiple slices of 36 GBMs, alongside with clinical and genomic data on those GBMs patients, were compiled from Ivy Glioblastoma Atlas Project – Allen Institute for Brain Science data sets. PDGF subunits show differential expression over distinct regions of GBM and PDGF family is heterogeneously expressed among different brain lobes affected by GBM. Further, PDGF family expression correlates with bad prognosis factors: age at GBM diagnosis, Phosphatase and Tensin Homolog deletion and Isocitrate Dehydrogenase 1 mutation. These findings may aid on clinical management of GBM and development of targeted curative therapies against this devastating tumour.
登录
查看更多内容
胶质母细胞瘤多形：外观其异质性。
影响因子：
5.2
作者：
Inda MM;Bonavia R;Seoane J
通讯作者：
Seoane J
影响因子：
4.6
作者：
Parker NR;Hudson AL;Khong P;Parkinson JF;Dwight T;Ikin RJ;Zhu Y;Cheng ZJ;Vafaee F;Chen J;Wheeler HR;Howell VM
通讯作者：
Howell VM
DOI：
10.1016/j.ijheatmasstransfer.2015.11.067
发表时间：
2016-04-01
影响因子：
5.2
作者：
Chen, Jie-Chao;Li, You-Rong;Wu, Chun-Mei
通讯作者：
Wu, Chun-Mei
影响因子：
10.5
作者：
Kim, Youngmi;Kim, Eunhee;Rich, Jeremy N.
通讯作者：
Rich, Jeremy N.
影响因子：
6.2
作者：
Funa, Keiko;Sasahara, Masakiyo
通讯作者：
Sasahara, Masakiyo