Three Decades of Research on O-GlcNAcylation - A Major Nutrient Sensor That Regulates Signaling, Transcription and Cellular Metabolism.
Three Decades of Research on O-GlcNAcylation - A Major Nutrient Sensor That Regulates Signaling, Transcription and Cellular Metabolism.
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DOI：
10.3389/fendo.2014.00183
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发表时间：
2014
影响因子：
5.2
通讯作者：
Hart GW
中科院分区：
文献类型：
--
作者：
Hart GW
尽管单糖o -连接n -乙酰氨基葡萄糖（o - glcnac酰化）对多肽的动态修饰在30多年前就被发现，但其作为调节无数细胞过程的主要营养传感器的生理意义直到最近才得到更广泛的认识。o - glcn酰化，无论是单独还是通过与其他翻译后修饰（如磷酸化、泛素化等）的相互作用，调节信号蛋白的活性，调节转录机制的大多数成分，影响细胞周期进程，调节无数其他调节蛋白的靶向/周转或功能，以响应营养物质。O-GlcNAc酰化的急性增加可以保护细胞免受应激性损伤，而O-GlcNAc循环的慢性失调有助于人类主要衰老疾病的病因，如糖尿病、癌症和神经变性。最近研究o - glcnac酰化的工具在个体位点水平和o - glcnac酰化循环的特异性抑制剂方面取得了进展，这使得阐明o - glcnac酰化在基本细胞过程中的特定功能取得了更快速的进展。
Even though the dynamic modification of polypeptides by the monosaccharide, O-linked N-acetylglucosamine (O-GlcNAcylation) was discovered over 30 years ago, its physiological significance as a major nutrient sensor that regulates myriad cellular processes has only recently been more widely appreciated. O-GlcNAcylation, either on its own or by its interplay with other post-translational modifications, such as phosphorylation, ubiquitination, and others, modulates the activities of signaling proteins, regulates most components of the transcription machinery, affects cell cycle progression and regulates the targeting/turnover or functions of myriad other regulatory proteins, in response to nutrients. Acute increases in O-GlcNAcylation protect cells from stress-induced injury, while chronic deregulation of O-GlcNAc cycling contributes to the etiology of major human diseases of aging, such as diabetes, cancer, and neurodegeneration. Recent advances in tools to study O-GlcNAcylation at the individual site level and specific inhibitors of O-GlcNAc cycling have allowed more rapid progress toward elucidating the specific functions of O-GlcNAcylation in essential cellular processes.
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影响因子：
3
作者：
Francisco, Herb;Kollins, Katherine;Varghis, Neal;Vocadlo, David;Vosseller, Keith;Gallo, Gianluca
通讯作者：
Gallo, Gianluca
影响因子：
4.3
作者：
Banerjee, Sulagna;Robbins, Phillips W.;Samuelson, John
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影响因子：
4.7
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Cole, RN;Hart, GW
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Hart, GW
影响因子：
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通讯作者：
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影响因子：
16.6
作者：
Hart GW;Slawson C;Ramirez-Correa G;Lagerlof O
通讯作者：
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