Effects of carotid and aortic chemoreceptor denervation in newborn piglets.
Effects of carotid and aortic chemoreceptor denervation in newborn piglets.
复制标题
颈动脉和主动脉化学感受器去神经支配对新生仔猪的影响。
DOI：
10.1152/japplphysiol.00819.2001
复制
发表时间：
2002
影响因子：
3.3
通讯作者：
H. Forster
中科院分区：
文献类型：
--
作者：
A. Serra;D. Brozoski;M. Hodges;S. Roethle;R. Franciosi;H. Forster
本研究的目的是检验以下假设：在新生仔猪中，假去神经或单独去主动脉神经（AOD）后不会出现通气不足，但颈动脉体去神经（CBD）后会出现短暂的通气不足，颈动脉和主动脉联合去神经（CBD+AOD）后通气不足最严重。在5、15和25日龄时，CBD和CBD+AOD仔猪去神经后出现显著（P < 0.05）的肺通气不足。CBD+AOD组5日龄去神经仔猪肺通气功能低下程度显著高于其他各组（P < 0.05）。相反，假去神经和AOD仔猪去神经后没有hypoprosthesis。注射氰化钠显示主动脉化学感受器是CBD后外周化学敏感性恢复的部位。预先注射5-羟色胺5a受体阻滞剂可消除主动脉氰化钠反应。CBD+AOD后残留的外周化疗敏感性定位于左心室。我们得出结论：1）主动脉化学感受器有助于5日龄时颈动脉去神经的仔猪的正常呼吸，2）CBD后存在多个残留外周化学敏感性部位。
The objective of the present study was to test the hypothesis that in neonatal piglets there would be no hypoventilation after sham denervation or aortic denervation (AOD) alone, but there would be transient hypoventilation after carotid body denervation (CBD) and the hypoventilation would be greatest after combined carotid and aortic denervation (CBD+AOD). There was a significant (P < 0.05) hypoventilation in CBD and CBD+AOD piglets denervated at 5, 15, and 25 days of age. The hypoventilation in CBD+AOD piglets denervated at 5 days of age was greater (P < 0.05) than that of all other groups. Conversely, sham-denervated and AOD piglets did not hypoventilate after denervation. Injections of sodium cyanide showed that aortic chemoreceptors were a site of recovery of peripheral chemosensitivity after CBD. This aortic sodium cyanide response was abolished by prior injection of a serotonin 5a receptor blocker. Residual peripheral chemosensitivity after CBD+AOD was localized to the left ventricle. We conclude that 1) aortic chemoreceptors contribute to eupneic breathing in piglets that were carotid denervated at 5 days of age and 2) there are multiple sites of residual peripheral chemosensitivity after CBD.
山羊颈动脉体中的多巴胺能兴奋可能是由血清素受体介导的。
影响因子：
--
作者：
O'Halloran,KD;Herman,JK;Janssen,PL;Bisgard,GE
通讯作者：
Bisgard,GE
DOI：
10.1016/s0034-5687(01)00242-0
发表时间：
2001-09-01
期刊：
RESPIRATION PHYSIOLOGY
影响因子：
--
作者：
Stunden, CE;Filosa, JA;Putnam, RW
通讯作者：
Putnam, RW
窦和主动脉神经切断后仔猪呼吸暂停时间延长，存活率受损。
DOI：
10.1152/jappl.1990.68.3.1048
发表时间：
1990
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Donnelly,DF;Haddad,GG
通讯作者：
Haddad,GG