Icariin promotes wound healing by enhancing the migration and proliferation of keratinocytes via the AKT and ERK signaling pathway.
Icariin promotes wound healing by enhancing the migration and proliferation of keratinocytes via the AKT and ERK signaling pathway.
复制标题
淫羊藿苷通过 AKT 和 ERK 信号通路增强角质形成细胞的迁移和增殖，从而促进伤口愈合。
DOI：
10.3892/ijmm.2018.3676
复制
发表时间：
2018-08
影响因子：
5.4
通讯作者：
Wu Y
中科院分区：
文献类型：
--
作者：
Mi B;Liu J;Liu G;Zhou W;Liu Y;Hu L;Xiong L;Ye S;Wu Y
淫羊藿苷是一种传统中药，长期以来被用来治疗多种疾病。在本研究中，研究了淫羊藿苷对皮肤伤口愈合的影响。体外实验表明淫羊藿苷通过激活AKT丝氨酸/苏氨酸激酶1（AKT）和细胞外信号调节激酶（ERK）显着促进角质形成细胞的迁移和增殖。抑制 AKT 或 ERK 可逆转淫羊藿苷对角质形成细胞增殖和迁移的影响。此外，淫羊藿苷还能抑制白细胞介素（IL）-6和肿瘤坏死因子（TNF）-α的产生，并诱导IL-10的产生。最后，动物实验证明淫羊藿苷治疗可加速伤口闭合速度。目前的研究结果表明，淫羊藿苷可能是一种有前景的药物，通过其上调 AKT 和 ERK 信号传导的作用，促进角质形成细胞的迁移和增殖，并加速皮肤伤口的愈合。
Icariin is a traditional Chinese drug that has long been used to treat various diseases. In the present study, the effect of icariin was investigated on cutaneous wound healing. Using in vitro experiments, it was demonstrated that icariin significantly promoted the migration and proliferation of keratinocytes via the activation of AKT serine/threonine kinase 1 (AKT) and extracellular signal-regulated kinase (ERK). Inhibition of AKT or ERK reversed the effects of icariin on the proliferation and migration of keratinocytes. In addition, icariin inhibited the production of interleukin (IL)-6 and tumor necrosis factor (TNF)-α and induced the production of IL-10. Finally, animal experiments demonstrated that icariin treatment accelerated the wound closure rate. The present findings revealed that icariin may be a promising drug to promote the migration and proliferation of keratinocytes, and to accelerate the healing of skin wounds, through its role in the upregulation of AKT and ERK signaling.
登录
查看更多内容
影响因子：
5
作者：
Jiang, Ming-Chun;Chen, Xiao-Han;Chen, Wen-Fang
通讯作者：
Chen, Wen-Fang
影响因子：
7.9
作者：
Chen, Wen-Fang;Wu, Lin;Wong, Man-Sau
通讯作者：
Wong, Man-Sau
影响因子：
4.3
作者：
Gu, Zhen-Fang;Zhang, Zi-Teng;Xu, Bao-Bin
通讯作者：
Xu, Bao-Bin
影响因子：
3.6
作者：
Zhao, Bin;Liu, Jia-Qi;Hu, Da-Hai
通讯作者：
Hu, Da-Hai
影响因子：
1.1
作者：
Gragnani, Alfredo;Müller, Bruno Rafael;Ferreira, Lydia Masako
通讯作者：
Ferreira, Lydia Masako