Is leptin an insulin counter‐regulatory hormone?
Is leptin an insulin counter‐regulatory hormone?
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瘦素是胰岛素反调节激素吗？
DOI：
10.1016/s0014-5793(96)01477-9
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发表时间：
1997
期刊：
影响因子：
3.5
通讯作者：
M. Alemany
中科院分区：
文献类型：
--
作者：
X. Remesar;I. Rafecas;J. Fernández‐López;M. Alemany
瘦素是ob基因的产物，通过下丘脑控制食欲，由于其受体的广泛分布，还可能影响许多其他组织。瘦素是由白色脂肪组织在高能量供应和胰岛素刺激的条件下合成的。糖皮质激素促进这种合成，而儿茶酚胺阻碍瘦素的产生。瘦素减少胰岛β细胞的胰岛素分泌，并诱导胰岛素抵抗。事实上，瘦素在负反馈循环中阻碍了胰岛素对WAT本身的作用。在对糖尿病患者、饥饿、再喂养以及胰岛素和葡萄糖钳夹的研究中获得的证据支持这种解释，这也可能解释了目前将瘦素与Wat质量大小信号传递给大脑的假设所遇到的部分困难。从本质上讲，瘦素可能是一种限制胰岛素以脂肪形式储存能量的逆调节激素，其影响包括减少食物摄入量，降低胰岛素分泌，增加对胰岛素的抵抗力，降低WAT对葡萄糖的摄取和脂肪合成。
Leptin, the product of the ob gene, controls appetite through the hypothalamus and may affect many other tissues because of the widespread distribution of its receptors. Leptin is synthesized by white adipose tissue (WAT) under conditions of high energy availability and insulin stimulus. Glucocorticoids enhance this synthesis and catecholamines hamper leptin production. Leptin diminishes insulin secretion by the pancreatic beta cells and induces insulin resistance. In fact leptin hampers insulin action on WAT itself in a negative feedback loop. The evidence acquired in studies on diabetics, starvation, refeeding and insulin and glucose clamps supports this interpretation, which may also explain part of the difficulties encountered by the current postulate that links leptin to WAT mass size signalling to the brain. Leptin may be, essentially, a counter-regulatory hormone limiting the insulin drive to store energy in the form of fat, its effects reaching from a decrease in food intake to lower insulin secretion and increased resistance to insulin and lower glucose uptake and fat synthesis by WAT.
影响因子：
20.3
作者：
M. Schwartz;D. Figlewicz;D. Baskin;S. Woods;D. Porte
通讯作者：
M. Schwartz;D. Figlewicz;D. Baskin;S. Woods;D. Porte