Projection targets of medial frontal D1DR-expressing neurons.
Projection targets of medial frontal D1DR-expressing neurons.
复制标题
表达D1DR的内侧D1DR神经元的投影靶标。
DOI：
10.1016/j.neulet.2017.06.057
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发表时间：
2017-08-10
影响因子：
2.5
通讯作者：
Narayanan NS
中科院分区：
文献类型：
--
作者：
Han SW;Kim YC;Narayanan NS
Prefrontal neurons expressing D1-type dopamine receptors (D1DRs) have been implicated in a variety of cognitive processes including working memory and timing. Although D1DRs are most strongly expressed on layer V/VI projection neurons, it is unknown which brain areas are specifically targeted by these projections. Here we selectively marked D1DR neurons using cre-loxP techniques with AAV carrying mCherry fluorescent protein, and traced projection targets of D1DR+ neurons in the mouse medial frontal cortex (MFC). We found relatively strong MFC D1DR+ projections to cortical areas as well as projections to basal ganglia and thalamic nuclei. We found relatively weaker MFC D1DR+ projections to the brainstem, hypothalamus, and other subcortical nuclei. These data intimate that MFC D1DR+ projections are well-positioned to powerfully influence cortical processing and have subcortical specificity. Thus MFC D1DR+ projection neurons may play a key role in tuning cortical networks during goal-directed behavior.
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DOI：
10.1016/j.cub.2016.11.029
发表时间：
2017-01-09
期刊：
Current biology : CB
影响因子：
--
作者：
Kim YC;Han SW;Alberico SL;Ruggiero RN;De Corte B;Chen KH;Narayanan NS
通讯作者：
Narayanan NS
影响因子：
16.2
作者：
Puig MV;Miller EK
通讯作者：
Miller EK
DOI：
10.1523/jneurosci.1367-12.2012
发表时间：
2012-08-01
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Seong HJ;Carter AG
通讯作者：
Carter AG
影响因子：
2.5
作者：
Parker, Krystal L.;Chen, Kuan-Hua;Narayanan, Nandakumar S.
通讯作者：
Narayanan, Nandakumar S.
影响因子：
11
作者：
Parker KL;Kim YC;Kelley RM;Nessler AJ;Chen KH;Muller-Ewald VA;Andreasen NC;Narayanan NS
通讯作者：
Narayanan NS