Mechanical restriction of intracortical vessel dilation by brain tissue sculpts the hemodynamic response.
Mechanical restriction of intracortical vessel dilation by brain tissue sculpts the hemodynamic response.
复制标题
DOI：
10.1016/j.neuroimage.2015.04.054
复制
发表时间：
2015-07-15
期刊：
影响因子：
5.7
通讯作者：
Drew PJ
中科院分区：
文献类型：
--
作者：
Gao YR;Greene SE;Drew PJ
了解脑血管扩张的空间动力学对于解读脑中血流动力学信号的血管基础是至关重要的。我们使用双光子显微镜成像的神经活动和血管动力学在清醒的行为小鼠在自主运动的躯体感觉皮层。动脉扩张内的组织学定义的前肢/后肢（FL/HL）的代表大于动脉扩张的躯体感觉皮层外的FL/HL的代表，表明在自然行为的血管反应是空间本地化。令人惊讶的是，我们发现，运动驱动的扩张表面血管的幅度近三倍的皮质内血管扩张。皮质内小动脉的较小扩张不是由于扩张饱和。解剖成像显示，与表面血管不同，皮质内血管被脑组织紧紧包围。一个数学模型表明，机械限制周围的脑组织皮质内血管可以解释相对于表面血管的皮质内血管扩张幅度降低。因此，在正常情况下，大脑的机械特性可能在塑造血流动力学反应的层状差异方面发挥重要作用。
Understanding the spatial dynamics of dilation in the cerebral vasculature is essential for deciphering the vascular basis of hemodynamic signals in the brain. We used two-photon microscopy to image neural activity and vascular dynamics in the somatosensory cortex of awake behaving mice during voluntary locomotion. Arterial dilations within the histologically-defined forelimb/hindlimb (FL/HL) representation were larger than arterial dilations in the somatosensory cortex immediately outside the FL/HL representation, demonstrating that the vascular response during natural behaviors was spatially localized. Surprisingly, we found that locomotion drove dilations in surface vessels that were nearly three times the amplitude of intracortical vessel dilations. The smaller dilations of the intracortical arterioles were not due to saturation of dilation. Anatomical imaging revealed that, unlike surface vessels, intracortical vessels were tightly enclosed by brain tissue. A mathematical model showed that mechanical restriction by the brain tissue surrounding intracortical vessels could account for the reduced amplitude of intracortical vessel dilation relative to surface vessels. Thus, under normal conditions, the mechanical properties of the brain may play an important role in sculpting the laminar differences of hemodynamic responses.
登录
查看更多内容
影响因子：
5.7
作者：
Chen BR;Bouchard MB;McCaslin AF;Burgess SA;Hillman EM
通讯作者：
Hillman EM
影响因子：
5.3
作者：
Chaigneau, Emmanuelle;Tiret, Pascale;Charpak, Serge
通讯作者：
Charpak, Serge
影响因子：
64.8
作者：
BOLOTINA, VM;NAJIBI, S;COHEN, RA
通讯作者：
COHEN, RA
影响因子：
16.2
作者：
Chen Q;Cichon J;Wang W;Qiu L;Lee SJ;Campbell NR;Destefino N;Goard MJ;Fu Z;Yasuda R;Looger LL;Arenkiel BR;Gan WB;Feng G
通讯作者：
Feng G
影响因子：
25
作者：
Blinder, Pablo;Tsai, Philbert S.;Kaufhold, John P.;Knutsen, Per M.;Suhl, Harry;Kleinfeld, David
通讯作者：
Kleinfeld, David