The cortical angiome: an interconnected vascular network with noncolumnar patterns of blood flow.
The cortical angiome: an interconnected vascular network with noncolumnar patterns of blood flow.
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DOI：
10.1038/nn.3426
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发表时间：
2013-07
影响因子：
25
通讯作者：
Kleinfeld, David
中科院分区：
文献类型：
--
作者：
Blinder, Pablo;Tsai, Philbert S.;Kaufhold, John P.;Knutsen, Per M.;Suhl, Harry;Kleinfeld, David
大脑皮层中允许大脑满足神经元计算的能量需求的血管结构的本质是什么？我们采用高通量组织学方法重建了小鼠触须初级感觉皮层多个立方毫米区域的完整血管结构和所有神经元体的位置。重建血管网。与与血管网络紧密相连的皮质柱的标准模型相比，图理论分析显示，地下微血管形成了相互连接的回路，其拓扑结构与柱的位置和边界保持不变。此外，计算出的血流模式在网络中与柱的位置无关。相反，通过穿透性小动脉获得的血液被穿透性小静脉有效地排出，以限制外侧灌注。这一分析为理解功能成像和穿透血管卒中对大脑活力的影响提供了基础。
What is the nature of the vascular architecture in the cortex that allows the brain to meet the energy demands of neuronal computations? We used high-throughput histology to reconstruct the complete angioarchitecture and the positions of all neuronal somata of multiple cubic millimeter regions of vibrissa primary sensory cortex in mouse. Vascular networks were derived from the reconstruction. In contrast with the standard model of cortical columns that are tightly linked with the vascular network, graph-theoretical analyses revealed that the subsurface microvasculature formed interconnected loops with a topology that was invariant to the position and boundary of columns. Furthermore, the calculated patterns of blood flow in the networks were unrelated to location of columns. Rather, blood sourced by penetrating arterioles was effectively drained by the penetrating venules to limit lateral perfusion. This analysis provides the underpinning to understand functional imaging and the effect of penetrating vessels strokes on brain viability.
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影响因子：
10.9
作者：
Kaufhold, John P.;Tsai, Philbert S.;Blinder, Pablo;Kleinfeld, David
通讯作者：
Kleinfeld, David
影响因子：
3.1
作者：
Eppihimer, MJ;Lipowsky, HH
通讯作者：
Lipowsky, HH
影响因子：
48
作者：
Drew, Patrick J.;Shih, Andy Y.;Driscoll, Jonathan D.;Knutsen, Per Magne;Blinder, Pablo;Davalos, Dimitrios;Akassoglou, Katerina;Tsai, Philbert S.;Kleinfeld, David
通讯作者：
Kleinfeld, David
DOI：
10.1073/pnas.88.24.11559
发表时间：
1991-12-01
影响因子：
11.1
作者：
GRINVALD, A;FROSTIG, RD;BARTFELD, E
通讯作者：
BARTFELD, E
DOI：
10.3389/fnene.2011.00001
发表时间：
2011-01-01
期刊：
Frontiers in neuroenergetics
影响因子：
--
作者：
Kleinfeld, David;Blinder, Pablo;Shih, Andy Y
通讯作者：
Shih, Andy Y