UVB-Induced Microvesicle Particle Release and Its Effects on the Cutaneous Microenvironment.
UVB-Induced Microvesicle Particle Release and Its Effects on the Cutaneous Microenvironment.
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DOI：
10.3389/fimmu.2022.880850
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
紫外线B辐射（UVB）对人体皮肤有深远的影响，可引起广泛的局部和全身免疫反应，是皮肤癌变的主要原因。光生物学研究的一个重要领域是UVB如何转化为效应信号。当皮肤暴露于UVB光时，亚细胞微泡颗粒（MVP）（生物活性细胞外囊泡的亚型）被释放，引起各种局部和全身免疫效应。在这篇综述中，我们强调角质形成细胞MVP释放在角质形成细胞中响应UVB。具体地，由UVB产生的血小板活化因子受体激动剂导致MVP从角质形成细胞释放。MVP释放的下游效应包括这些亚细胞颗粒转运包括甘油磷酸胆碱衍生的脂质介质血小板活化因子（PAF）在内的试剂的能力。此外，尽管UVB仅在表皮中吸收，但似乎从MVP释放的PAF也介导全身免疫抑制并增强肿瘤生长和转移。表达PAF受体的肿瘤细胞可以利用这种机制来逃避化疗反应，导致晚期癌症如黑色素瘤的治疗抗性。此外，新的药理学试剂提供了更深入的了解UVB诱导的免疫反应途径和药理学干预的潜在目标。本文综述了需要更清楚地阐明的机制，UVB照射与皮肤免疫反应及其病理表现。对这一过程的进一步理解可以为UVB相关疾病从致癌到光敏性带来新的见解和治疗策略。
Ultraviolet B radiation (UVB) has profound effects on human skin that results in a broad spectrum of immunological local and systemic responses and is the major cause of skin carcinogenesis. One important area of study in photobiology is how UVB is translated into effector signals. As the skin is exposed to UVB light, subcellular microvesicle particles (MVP), a subtype of bioactive extracellular vesicles, are released causing a variety of local and systemic immunological effects. In this review, we highlight keratinocyte MVP release in keratinocytes in response to UVB. Specifically, Platelet-activating factor receptor agonists generated by UVB result in MVP released from keratinocytes. The downstream effects of MVP release include the ability of these subcellular particles to transport agents including the glycerophosphocholine-derived lipid mediator Platelet-activating factor (PAF). Moreover, even though UVB is only absorbed in the epidermis, it appears that PAF release from MVPs also mediates systemic immunosuppression and enhances tumor growth and metastasis. Tumor cells expressing PAF receptors can use this mechanism to evade chemotherapy responses, leading to treatment resistance for advanced cancers such as melanoma. Furthermore, novel pharmacological agents provide greater insight into the UVB-induced immune response pathway and a potential target for pharmacological intervention. This review outlines the need to more clearly elucidate the mechanism linking UVB-irradiation with the cutaneous immune response and its pathological manifestations. An improved understanding of this process can result in new insights and treatment strategies for UVB-related disorders from carcinogenesis to photosensitivity.
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影响因子：
30.5
作者：
Acosta-Rodriguez, Eva V.;Napolitani, Giorgio;Sallusto, Federica
通讯作者：
Sallusto, Federica
影响因子：
3.8
作者：
de Oliveira, Soraya I.;Andrade, Luciana N. S.;Jancar, Sonia
通讯作者：
Jancar, Sonia
影响因子：
4.4
作者：
Darst, M;Al-Hassani, M;Travers, JB
通讯作者：
Travers, JB
影响因子：
3.3
作者：
Bihl JC;Rapp CM;Chen Y;Travers JB
通讯作者：
Travers JB
影响因子：
4.6
作者：
Drolet AM;Thivierge M;Turcotte S;Hanna D;Maynard B;Stankovà J;Rola-Pleszczynski M
通讯作者：
Rola-Pleszczynski M