Arterial wave reflection is associated with severity of extracoronary atherosclerosis in patients with coronary artery disease
Arterial wave reflection is associated with severity of extracoronary atherosclerosis in patients with coronary artery disease
复制标题
动脉波反射与冠状动脉疾病患者冠状动脉外动脉粥样硬化的严重程度相关
DOI：
10.1097/01.hjr.0000198446.18989.4f
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发表时间：
2006
影响因子：
8.3
通讯作者：
M. Mavrikakis
中科院分区：
文献类型：
--
作者：
J. Lekakis;I. Ikonomidis;A. Protogerou;T. Papaioannou;K. Stamatelopoulos;C. Papamichael;M. Mavrikakis
背景动脉波反射是左心室功能、冠状动脉灌注和心血管风险的主要决定因素。我们研究了动脉波反射是否可以检测有记录的冠状动脉疾病（CAD）患者的外周动脉粥样硬化。方法对184例经冠状动脉造影证实的冠心病患者进行桡动脉压平张力计和脉搏波分析，测量中心血压和增强指数（AI）。以踝肱指数（ABI）和颈动脉内膜中层厚度（IMT）作为下肢动脉粥样硬化的指标。结果IMT> 0.7mm或ABI <0.94者的AI高于IMT较低或ABI较高者（分别为24 ± 17 vs 17 ± 16%，23 ± 18 vs 18 ± 13%，P<0.05）。多因素分析显示，年龄、女性、心率、平均血压、高脂血症、他汀类药物的使用与Al增加相关（回归系数（β）分别为0.50、0.15、-0.60、0.23、0.16和-0.14，P<0.05）。Al增加与IMT异常的校正比值比为1.035 [95%置信区间（CI），1.005-1.066]，P=0.02，与IMT异常的校正比值比为1.08 [95%置信区间（CI），1.005-1.066]，（95%CI，1.024-1.146），校正年龄、性别、心率、身高、血压、动脉粥样硬化危险因素后，ABI P= 0.005，肥胖和药物治疗。Al与Gensini评分或冠状动脉病变血管数之间无相关性。结论增强指数是冠心病患者冠状动脉外广泛粥样硬化的一个指标。
Background Arterial wave reflection is a major determinant of left ventricular function, coronary perfusion and cardiovascular risk. We investigated whether arterial wave reflection may detect atherosclerosis of peripheral arteries in patients with documented coronary artery disease (CAD). Methods Radial artery applanation tonometry and pulse wave analysis was performed in 184 patients with documented CAD at coronary angiography; central blood pressures and augmentation index (AI) were measured. Ankle-brachial (ABI) index and intima-media thickness (IMT) were used as indices of atherosclerosis of the lower limbs and the carotid arteries respectively. Results Patients with abnormal IMT (>0.7 mm, first tertile) or ABI (<0.94, first tertile) had higher Al than patients with lower IMT or higher ABI (24 ± 17 versus 17 ± 16% and 23 ± 18 versus 18 ± 13%, respectively, P<0.05). In multivariate analysis, increasing Al was associated with age, female gender, heart rate, mean blood pressure, hyperlipidaemia, and use of statins (regression coefficient (β) = 0.50, β = 0.15, β=-0.60, β = 0.23, β = 0.16 and β=-0.14, respectively, P<0.05). Increasing Al was associated with an adjusted-odds ratio of 1.035 [95% confidence interval (CI), 1.005–1.066], P=0.02 for an abnormal IMT and of 1.08 (95% CI, 1.024–1.146), P= 0.005 for ABI after adjustment for age, gender, heart rate, height, blood pressure, atherosclerotic risk factors, obesity and medication. No relation was found between Al and Gensini score or for the number of diseased coronary vessels. Conclusion Augmentation index is a marker of extensive extracoronary atherosclerosis in patients with CAD.
影响因子：
37.8
作者：
Chen-Huan Chen-Chen-Huan-Chen-10355153;E. Nevo;B. Fetics;P. Pak;F. Yin;W. Maughan;D. Kass
通讯作者：
Chen-Huan Chen-Chen-Huan-Chen-10355153;E. Nevo;B. Fetics;P. Pak;F. Yin;W. Maughan;D. Kass
影响因子：
37.8
作者：
Franklin, SS;Khan, SA;Levy, D
通讯作者：
Levy, D
影响因子：
37.8
作者：
HIATT, WR;HOAG, S;HAMMAN, RF
通讯作者：
HAMMAN, RF