Shuganjieyu capsule increases neurotrophic factor expression in a rat model of depression.
Shuganjieyu capsule increases neurotrophic factor expression in a rat model of depression.
复制标题
舒肝解郁胶囊增加抑郁大鼠模型中神经营养因子的表达。
DOI：
10.4103/1673-5374.130067
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发表时间：
2014-03-01
影响因子：
6.1
通讯作者：
Liu Y
中科院分区：
文献类型：
--
作者：
Fu J;Zhang Y;Wu R;Zheng Y;Zhang X;Yang M;Zhao J;Liu Y
Shuganjieyu capsule has been approved for clinical treatment by the State Food and Drug Ad-ministration of China since 2008. In the clinic, Shuganjieyu capsule is often used to treat mild to moderate depression. In the rat model of depression established in this study, Shuganjieyu capsule was administered intragastrically daily before stress. Behavioral results confirmed that depressive symptoms lessened after treatment with high-dose (150 mg/kg) Shuganjieyu capsule. Immunohistochemistry results showed that high-dose Shuganjieyu capsule significantly increased phosphorylation levels of phosphorylation cyclic adenosine monophosphate response element binding protein and brain-derived neurotrophic factor expression in the medial prefrontal cortex and hippocampal CA3 area. Overall, our results suggest that in rats, Shuganjieyu capsule effec-tively reverses depressive-like behaviors by increasing expression levels of neurotrophic factors in the brain.
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影响因子：
4.2
作者：
Kiss, Janos P.
通讯作者：
Kiss, Janos P.
影响因子：
9.8
作者：
Hamet, P;Tremblay, J
通讯作者：
Tremblay, J
影响因子：
5.6
作者：
Fuchs, E;Czéh, B;Lucassen, PJ
通讯作者：
Lucassen, PJ
影响因子：
3.5
作者：
Chen, Michael J.;Russo-Neustadt, Amelia A.
通讯作者：
Russo-Neustadt, Amelia A.
影响因子：
3.8
作者：
Luo, D. D.;An, S. C.;Zhang, X.
通讯作者：
Zhang, X.