Pathophysiology and mechanisms of severe retinopathy of prematurity.
Pathophysiology and mechanisms of severe retinopathy of prematurity.
复制标题
DOI：
10.1016/j.ophtha.2014.07.050
复制
发表时间：
2015-01
期刊：
影响因子：
13.7
通讯作者：
Hartnett, M. Elizabeth
中科院分区：
文献类型：
--
作者：
Hartnett, M. Elizabeth
早产儿视网膜病变（ROP）仅影响早产儿，但随着世界许多地区早产儿的增加，ROP已成为儿童失明的主要原因。致盲可能是由于异常发育的血管生成导致纤维血管性视网膜脱离。为了治疗严重的ROP，重要的是研究ROP中正常发育的血管生成以及激活病理信号事件和异常血管生成的应激。血管内皮生长因子（VEGF）信号传导在生理和病理性发育血管生成中都是重要的。基于氧诱导视网膜病变（OIR）动物模型的研究，氧水平、“氧化应激”、炎症和营养能力等外源性因素已通过涉及缺氧诱导因子和血管生成因子（如VEGF）的失调信号通路与严重ROP相关。、氧化物质和神经保护性生长因子导致ROP的“阶段”。这篇转化科学综述将重点关注在代表人类ROP的OIR动物模型中进行的研究，并强调几个领域：通过过度激活VEGF受体2（VEGFR2）信号传导导致血管异常生长进入玻璃体而不是进入视网膜的机制，靶向不同细胞进入视网膜以抑制异常血管生成和促进生理性视网膜血管发育的重要性，广泛和靶向抑制VEGF生物活性的毒性，以及VEGF在视网膜发育中的神经保护作用。几个未来的翻译治疗进行了讨论，包括VEGF信号的靶向抑制，而不是广泛的玻璃体内抗VEGF治疗的考虑。
Retinopathy of prematurity (ROP) affects only premature infants, but as premature births increase in many areas of the world, ROP has become a leading cause of childhood blindness. Blindness can occur from aberrant developmental angiogenesis that leads to fibrovascular retinal detachment. In order to treat severe ROP, it is important to study normal developmental angiogenesis and the stresses that activate pathologic signaling events and aberrant angiogenesis in ROP. Vascular endothelial growth factor (VEGF) signaling is important in both physiologic and pathologic developmental angiogenesis. Based on studies in animal models of oxygen-induced retinopathy (OIR), exogenous factors such as oxygen levels, “oxidative stress,” inflammation, and nutritional capacity have been linked to severe ROP through dysregulated signaling pathways involving hypoxia inducible factors and angiogenic factors like VEGF, oxidative species, and neuroprotective growth factors to cause “phases” of ROP. This translational science review will focus on studies performed in animal models of OIR representative of human ROP and highlight several areas: mechanisms for aberrant growth of blood vessels into the vitreous rather than into the retina through over activation of VEGF receptor 2 (VEGFR2) signaling, the importance of targeting different cells into the retina in order to inhibit aberrant angiogenesis and promote physiologic retinal vascular development, toxicity from broad and targeted inhibition of VEGF bioactivity, and the role of VEGF in neuroprotection in retinal development. Several future translational treatments are discussed, including considerations for targeted inhibition of VEGF signaling instead of broad intravitreal anti-VEGF treatment.
登录
查看更多内容
影响因子：
3.6
作者：
Di Fiore, Juliann M.;Kaffashi, Farhad;Loparo, Kenneth;Sattar, Abdus;Schluchter, Mark;Foglyano, Ryan;Martin, Richard J.;Wilson, Christopher G.
通讯作者：
Wilson, Christopher G.
影响因子：
4.4
作者：
Greenberg, Kenneth P.;Geller, Scott F.;Flannery, John G.
通讯作者：
Flannery, John G.
影响因子：
4.4
作者：
Lutty, Gerard A.;McLeod, D. Scott;Wiegand, Stanley J.
通讯作者：
Wiegand, Stanley J.
影响因子：
4.4
作者：
Capozzi, Megan E.;McCollum, Gary W.;Penn, John S.
通讯作者：
Penn, John S.
DOI：
10.1056/nejmra1208129
发表时间：
2012-12-27
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hartnett ME;Penn JS
通讯作者：
Penn JS