The relationship between patterns of intermittent hypoxia and retinopathy of prematurity in preterm infants.
The relationship between patterns of intermittent hypoxia and retinopathy of prematurity in preterm infants.
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DOI：
10.1038/pr.2012.132
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发表时间：
2012-12
影响因子：
3.6
通讯作者：
Wilson, Christopher G.
中科院分区：
文献类型：
--
作者：
Di Fiore, Juliann M.;Kaffashi, Farhad;Loparo, Kenneth;Sattar, Abdus;Schluchter, Mark;Foglyano, Ryan;Martin, Richard J.;Wilson, Christopher G.
我们之前已经表明，患有严重早产儿视网膜病变（ROP）的早产儿间歇性低氧血症事件（IH）的发生率增加。动物模型表明IH事件的模式也可能在ROP严重程度中起作用。我们假设特定的IH模式与早产儿ROP相关。评估了IH持续时间、严重程度和IH之间的时间间隔（≤ 80%、≥10秒和≤ 3 min）沿着氧饱和度（SpO 2）波形频谱的变异性。重度ROP与1）IH持续时间的平均值和标准差增加相关（p<0.005），2）变异性更大IH之间的时间间隔（直方图熵）（p<0.005），3）较高的IH最低值（p<0.05），4）1- 20 min的IH时间间隔（p<0.05）和5）在0.002-0.008Hz范围内增加频谱功率（p<0.05），对应于持续2-8分钟的SpO 2波形振荡。光谱差异早在14天的生活。重度ROP与更多变量、更长时间和较轻的IH事件相关。识别SpO 2波形中的特定频谱成分可能有助于早期识别有严重ROP风险的婴儿。
We have previously shown an increased incidence of intermittent hypoxemic events (IH) in preterm infants with severe retinopathy of prematurity (ROP). Animal models suggest that patterns of IH events may play a role in ROP severity as well. We hypothesize that specific IH patterns are associated with ROP in preterm infants. Variability in IH duration, severity and the time interval between IH (≤80%, ≥10 seconds and ≤3min) along with the frequency spectrum of the oxygen saturation (SpO2) waveform were assessed. Severe ROP was associated with 1) an increased mean and standard deviation of the duration of IH (p<0.005), 2) more variability (Histogram Entropy) of the time interval between IH (p<0.005), 3) a higher IH nadir (p<0.05), 4) a time interval between IH of 1–20min (p<0.05) and 5) increased spectral power in the range of 0.002–0.008Hz (p<.05), corresponding to SpO2 waveform oscillations of 2–8 minutes in duration. Spectral differences were detected as early as 14 days of life. Severe ROP was associated with more variable, longer, and less severe IH events. Identification of specific spectral components in the SpO2 waveform may assist in early identification of infants at risk for severe ROP.
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影响因子：
1.4
作者：
Hartnett, M. Elizabeth
通讯作者：
Hartnett, M. Elizabeth
影响因子：
5.1
作者：
Di Fiore, Juliann M.;Bloom, Jeffrey N.;Martin, Richard J.
通讯作者：
Martin, Richard J.
影响因子：
--
作者：
SHANNON, CE
通讯作者：
SHANNON, CE
影响因子：
3.6
作者：
PENN, JS;HENRY, MM;TOLMAN, BL
通讯作者：
TOLMAN, BL
影响因子：
13.7
作者：
Sears, Jonathan E.;Pietz, Jeffrey;Hoppe, George
通讯作者：
Hoppe, George